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History of Modern Psychopharmacology: A Personal View With an Emphasis on Antidepressants

Domino, Edward F. MD

Special Issue: Psychopharmacology and Psychosomatic Research

Objective: This article provides the chemical basis for the molecular modification of H1 antihistamines in the rational development of some antidepressant and antipsychotic drugs.

Methods: A review of the literature and personal experiences have been compiled.

Conclusions: The contributions of many basic scientists, the crucial observations of clinicians, and the desire of the drug industry to make money have resulted in the currently available psychopharmacological treatments. The future development of psychopharmacology depends on better clinical research to generate new hypotheses of the chemical and behavioral pathology of mental disease. Psychosomatic medicine can make a unique contribution in its interdisciplinary role of stressing brain, body, and mind relationships.

From the Professor, Department of Pharmacology, University of Michigan, Ann Arbor, Michigan.

Received for publication June 2, 1998;

revision received January 27, 1999.

Address reprint requests to: E. F. Domino, MD, Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-0632.

Copyright © 1999 by American Psychosomatic Society
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