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Treatment Duration With Long-Acting Injectable Antipsychotics After In-hospital Initiation: A Retrospective Cohort Study

Rittmannsberger, Hans MD; Rosenleitner, Jan MD; Malsiner-Walli, Gertraud PhD; Werl, Regina MD; Rittmannsberger, Barbara MSc; Yazdi, Kurosch MD

Journal of Clinical Psychopharmacology: April 2017 - Volume 37 - Issue 2 - p 250–254
doi: 10.1097/JCP.0000000000000672
Brief Reports

Purpose: Long-acting injectable (LAI) antipsychotics are recommended especially for patients with multiple admissions and poor adherence. The empirical basis of this strategy is a matter of debate.

Methods: In a retrospective cohort study extending over 6 years, all patients admitted for inpatient treatment with a diagnosis of psychotic disorders according to International Statistical Classification of Diseases and Related Health Problems, 10th Revision (F2) were screened for treatment episodes with a new start of an LAI. Indication for LAI treatment was based primarily on previous medication default. All-cause discontinuation was used as a measure of treatment efficiency. Patients with early dropout (termination of LAI treatment within 6 months) were compared with patients with longer treatment (treatment >6 months) for sociodemographic and treatment variables using bivariate and multivariate analyses.

Results: A total of 194 treatment episodes with new start of LAIs were identified. Almost one half dropped out within 6 months (early dropout: n = 95 [49%]; mean duration, 2.2 months). Termination of treatment was mainly due to patients’ refusal to continue. However, almost a third of patients (61; 31.4%) had a treatment duration of more than 2 years. In a multivariate Cox regression model, longer treatment duration was associated with older age (P = 0.05), not being single (P = 0.04), fewer admissions during the year preceding the index episode (P = 0.02), and better ratings for adherence at the index episode (P = 0.03).

Conclusions: There are both more patients than expected leaving the treatment early and more patients than expected staying for long periods, even among patients with a history of poor adherence.

From the *Department of Psychiatry 1, Kepler University Hospital, Linz; †Department of Psychiatry, General Hospital Steyr, Steyr; and ‡Institute of Applied Statistics, Johannes-Kepler University, Linz, Austria.

Received August 25, 2016; accepted after revision December 29, 2016.

Reprints: Hans Rittmannsberger, MD, Department of Psychiatry, General Hospital Steyr, Sierningerstraße 170, 4400 Steyr, Austria (e-mail:

This work was supported in part by an unrestricted grant by the company Janssen-Cilag.

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