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Journal of Clinical Psychopharmacology:
doi: 10.1097/
Improvement Without Impairment in Psychotic and Mood Disorders

Effects of Antipsychotics on Sexual and Endocrine Function in Women: Implications for Clinical Practice

Smith, Shubulade MBBS, MRCPsych

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Typical antipsychotic agents are commonly associated with hyperprolactinemia, which, in turn, leads to sexual dysfunction. The mechanism of action underlying this clinical phenomenon is mediated by the dopamine-blocking action of typical antipsychotic medications, which results in excessive prolactin secretion and secondary effects on gonadal function. This antipsychotic-induced sexual dysfunction is unacceptable to patients and is associated with nonadherence to medication, impacting on the overall clinical outcome and treatment success. Development of first-line atypical antipsychotic agents that do not affect prolactin production is therefore an important advance for patients requiring long-term antipsychotic therapy.

© 2003 Lippincott Williams & Wilkins, Inc.


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