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5-HT2A receptor gene promoter polymorphism –1438A/G and bipolar disorder

Chee, I. S.a; Lee, S. W.a; Kim, J. L.a; Wang, S. K.a; Shin, Y. O.a; Shin, S. C.a; Lee, Y. H.b; Hwang, H. M.b; Lim, M. R.b

Research Papers

Genetic factors, such as the genes involved in the serotonin pathway, probably play an important role in the pathogenesis of bipolar disorder, and serotonin type 2A (5-HT2A) receptor gene promoter polymorphism –1438A/G has been reported. This study investigated the association between –1438A/G polymorphism of 5-HT2A receptor gene promoter and bipolar disorder in a Korean population. Using the polymerase chain reaction, –1438A/G polymorphism typed in 142 patients with bipolar disorder and in 148 normal control subjects. Differences in genotype distributions and allele frequencies of –1438A/G between patients with bipolar disorder and normal control subjects were tested for significance using the chi-squared test. There were significant differences in genotype distributions [χ2 = 9.697, degrees of freedom (df) = 2, P  = 0.008] and allele frequencies (χ2 = 7.284, df = 1, P  = 0.007) of –1438A/G between patients with bipolar disorder and normal control subjects. Although further studies are necessary, these results in a Korean population suggest that –1438A/G polymorphism of 5-HT2A receptor gene promoter may be causally related to the development of bipolar disorder.

aDepartment of Psychiatry, Chungnam National University Hospital, College of Medicine, Chungnam National University, Taejon, Korea; bDepartment of Anatomy, College of Medicine, Chungnam National University, Taejon, Korea

Correspondence to Ik-Seung Chee MD, Department of Psychiatry, Chungnam National University Hospital, College of Medicine, Chungnam National University, 640 Daesa-Dong, Jung-Ku, Taejon 301-721, Korea. E-mail: ischee@cnu.ac.kr

Received 1 June 2001

Revised 7 June 2001

Accepted 7 June 2001

© 2001 Lippincott Williams & Wilkins, Inc.