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5-HT2A receptor gene promoter polymorphism 1438A/G and bipolar disorder

Chee, I. S.a; Lee, S. W.a; Kim, J. L.a; Wang, S. K.a; Shin, Y. O.a; Shin, S. C.a; Lee, Y. H.b; Hwang, H. M.b; Lim, M. R.b

Psychiatric Genetics:
Research Papers
Abstract

Genetic factors, such as the genes involved in the serotonin pathway, probably play an important role in the pathogenesis of bipolar disorder, and serotonin type 2A (5-HT2A) receptor gene promoter polymorphism –1438A/G has been reported. This study investigated the association between –1438A/G polymorphism of 5-HT2A receptor gene promoter and bipolar disorder in a Korean population. Using the polymerase chain reaction, –1438A/G polymorphism typed in 142 patients with bipolar disorder and in 148 normal control subjects. Differences in genotype distributions and allele frequencies of –1438A/G between patients with bipolar disorder and normal control subjects were tested for significance using the chi-squared test. There were significant differences in genotype distributions [χ2 = 9.697, degrees of freedom (df) = 2, P  = 0.008] and allele frequencies (χ2 = 7.284, df = 1, P  = 0.007) of –1438A/G between patients with bipolar disorder and normal control subjects. Although further studies are necessary, these results in a Korean population suggest that –1438A/G polymorphism of 5-HT2A receptor gene promoter may be causally related to the development of bipolar disorder.

Author Information

aDepartment of Psychiatry, Chungnam National University Hospital, College of Medicine, Chungnam National University, Taejon, Korea; bDepartment of Anatomy, College of Medicine, Chungnam National University, Taejon, Korea

Correspondence to Ik-Seung Chee MD, Department of Psychiatry, Chungnam National University Hospital, College of Medicine, Chungnam National University, 640 Daesa-Dong, Jung-Ku, Taejon 301-721, Korea. E-mail: ischee@cnu.ac.kr

Received 1 June 2001

Revised 7 June 2001

Accepted 7 June 2001

© 2001 Lippincott Williams & Wilkins, Inc.