Psychiatric Genetics

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Psychiatric Genetics:
doi: 10.1097/YPG.0000000000000038
Brief Association Letters

Analysis of gastrin-releasing peptide gene and gastrin-releasing peptide receptor gene in patients with agoraphobia

Zimmermann, Katrina,*; Görgens, Heikeb,*; Bräuer, Davidd,f; Einsle, Franziskad; Noack, Barbarac; von Kannen, Stephanieb; Grossmann, Mariab; Hoyer, Jürgend; Strobel, Alexandere; Köllner, Volkerg; Weidner, Kerstina; Ziegler, Andreash,i; Hemmelmann, Claudiah; Schackert, Hans K.b

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Abstract

A gastrin-releasing peptide receptor (GRPR) knock-out mouse model provided evidence that the gastrin-releasing peptide (GRP) and its neural circuitry operate as a negative feedback-loop regulating fear, suggesting a novel candidate mechanism contributing to individual differences in fear-conditioning and associated psychiatric disorders such as agoraphobia with/without panic disorder. Studies in humans, however, provided inconclusive evidence on the association of GRP and GRPR variations in agoraphobia with/without panic disorder. Based on these findings, we investigated whether GRP and GRPR variants are associated with agoraphobia. Mental disorders were assessed via the Munich-Composite International Diagnostic Interview (M-CIDI) in 95 patients with agoraphobia with/without panic disorder and 119 controls without any mental disorders. A complete sequence analysis of GRP and GRPR was performed in all participants. We found no association of 16 GRP and 7 GRPR variants with agoraphobia with/without panic disorder.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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