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Are TMEM genes potential candidate genes for panic disorder?

Gregersen, Noomi O.a,b,c; Buttenschøn, Henriette N.a,c; Hedemand, Anneb,c; Dahl, Hans A.e; Kristensen, Ann S.d; Clementsen, Biritai; Woldbye, David P.D.g; Koefoed, Pernilleg; Erhardt, Angelikaj; Kruse, Torben A.f; Wang, August G.h,i; Børglum, Anders D.b,c,d; Mors, Olec,d

doi: 10.1097/YPG.0000000000000022
Brief Reports

We analysed single nucleotide polymorphisms in two transmembrane genes (TMEM98 and TMEM132E) in panic disorder (PD) patients and control individuals from the Faroe Islands, Denmark and Germany. The genes encode single-pass membrane proteins and are located within chromosome 17q11.2–q12, a previously reported candidate region for PD. Three single nucleotide polymorphisms (rs887231, rs887230 and rs4795942) located upstream and within TMEM132E showed a nominal significant association with PD primarily in the Danish cohort. No nominal significant associations were observed between TMEM98 and PD. Our data indicate that TMEM132E might contribute moderately towards the risk of developing PD.

aTranslational Neuropsychiatry Unit, Department of Clinical Medicine

bDepartment of Biomedicine and Centre for Integrative Sequencing (iSEQ), Aarhus University

cThe Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)

dResearch Department P, Aarhus University Hospital, Risskov

eAmplexa Genetics A/S

fDepartment of Clinical Genetics, University of Southern Denmark, Odense

gLaboratory of Neuropsychiatry, University of Copenhagen

hDepartment of Psychiatry, HS Amager Hospital, Copenhagen University Hospital, Copenhagen, Denmark

iDepartment of Psychiatry, the National Hospital, Torshavn, Faroe Islands

jMax Planck Institute of Psychiatry, Munich, Germany

Correspondence to Noomi O. Gregersen, Cand Scient, Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Skovagervej 2, 8240 Risskov, Denmark Tel: +45 7847 1167; fax: +45 7847 1108; e-mail: noomigregersen@mac.com

Received March 8, 2013

Accepted October 8, 2013

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins