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Nonsynonymous polymorphisms of the PDLIM5 gene association with the occurrence of both bipolar disorder and schizophrenia

Zain, Mohd A.a; Roffeei, Siti N.a; Zainal, Nor Z.b; Kanagasundram, Sharmillab; Mohamed, Zahurina

doi: 10.1097/YPG.0000000000000015
Brief Reports

Two single nucleotide polymorphisms of PDLIM5, rs7690296 and rs11097431, were genotyped using Mass-Array SNP genotyping by Sequenom technology in 244 bipolar disorder patients, 471 schizophrenia patients, and 601 control individuals who were Malay, Chinese, and Indian ethnic groups in the Malaysian population. A significant association was observed in allele frequency between the rs7690296 polymorphism and bipolar disorder in the Indian ethnic group [P=0.02, adjusted odds ratio (OR) 0.058, 95% confidence interval (CI) 0.36–0.93]. A significant association was also observed between the rs7690296 polymorphism and schizophrenia under the recessive model for both Malay (P=0.02, adjusted OR 1.86, 95% CI 1.12–3.10) and Indian (P=0.02, adjusted OR 1.92, 95% CI 1.10–3.37) ethnic groups. However, no association was detected between the rs11097431 polymorphism either with bipolar disorder or with schizophrenia. Therefore, it can be deduced that the nonsynonymous rs7690296 polymorphism could play an important role in the pathophysiology of both bipolar disorder and schizophrenia.

aThe Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine

bDepartment of Psychological Medicine, University of Malaya, Kuala Lumpur, Malaysia

Correspondence to Mohd A. Zain, MMedSc, The Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia Tel: +603 7967 4703; fax: +603 7967 4791; e-mail: aizat03@gmail.com

Received December 9, 2012

Accepted August 12, 2013

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins