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Association between corticotropin-releasing hormone receptor 1 and 2 (CRHR1 and CRHR2) gene polymorphisms and personality traits

Ishitobi, Yoshinobu; Nakayama, Shinya; Kanehisa, Masayuki; Higuma, Haruka; Maruyama, Yoshihiro; Okamoto, Shizuko; Inoue, Ayako; Imanaga, Junko; Tanaka, Yoshihiro; Tsuru, Jusen; Hanada, Hiroaki; Akiyoshi, Jotaro

doi: 10.1097/YPG.0000000000000002
Brief Reports

Previous studies have reported that the hypothalamic–pituitary–adrenal axis is involved with personality traits. We examined the association between corticotropin-releasing hormone receptor (CRHR) genes and personality traits. We investigated the 12 single-nucleotide polymorphisms of intron CRHR (six in CRHR1 and six in CRHR2, respectively) in 218 healthy volunteers using TaqMan PCR assays. Personality traits were assessed using the Revised NEO-Personality Inventory, the Temperament and Character Inventory, and the State-Trait Anxiety Inventory. No significant associations were observed between CRHR1 and CRHR2 expression and personality traits. These results fail to provide support for an association of CRHR1 and CRHR2 with personality traits in a Japanese adult population.

Department of Neuropsychiatry, Faculty of Medicine, Oita University, Oita, Japan

Correspondence to Jotaro Akiyoshi, MD, PhD, Department of Neuropsychiatry, Faculty of Medicine, Oita University, Hasama-Machi, Yufu-Shi, Oita 879-5593, Japan Tel: +81 97 586 5823; fax: +81 97 549 3583; e-mail:

Received January 9, 2013

Accepted August 3, 2013

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins