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Genetic variation of FYN contributes to the molecular mechanisms of coping styles in healthy Chinese-Han participants

Zhao, Xiaofeng*; Li, Jingying*; Huang, Yinglin; Jin, Qiu; Ma, Hui; Wang, Yuan; Wu, Lijuan; Li, Jun; Zhu, Gang

doi: 10.1097/YPG.0b013e328364365d
Brief Reports

Genetic factors can influence specific human coping styles. Polymorphisms in the Src family tyrosine kinase FYN gene have been associated with several personality traits, but no studies have examined the possible relationship between FYN alleles and coping styles. To this end, we examined the association between three single nucleotide polymorphisms of FYN (rs706895, rs3730353, and rs6916861) and coping styles as measured by the Simplified Coping Style Questionnaire in 488 healthy Chinese-Han individuals. In the total sample population, there were no significant differences in the scores for active coping and passive coping among the genotypes of these three polymorphisms. In sex-specific analyses, however, both rs3730353 and rs6916861 polymorphisms showed a significant relationship with passive coping scores in female participants (rs3730353: χ2=8.08, P=0.018; rs6916861: χ2=7.78, P=0.020). Our results provided suggestive evidence that the FYN gene contributes toward the variance in human coping styles.

Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, China

*Xiaofeng Zhao and Jingying Li contributed equally to the writing of this article.

Correspondence to Gang Zhu, MD, PhD, Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang 110001, China Tel/fax: +86 24 83282184; e-mail: gzhu@mail.cmu.edu.cn

Received June 4, 2012

Accepted January 8, 2013

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins