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An association study between the norepinephrine transporter gene and depression

Buttenschøn, Henriette N.b,d; Jacobsen, Iben S.b; Grynderup, Matias B.a; Hansen, Åse M.e,g; Kolstad, Henrik A.a; Kaerlev, Lindaa,j; Thomsen, Jane F.f; Nordentoft, Mereted,h; Silahtaroglu, Aslii; Tommerup, Nielsi; Tümer, Zeynepi,k; Krogh, Jesperh; Børglum, Anders D.c,d,l; Mors, Oled,l

doi: 10.1097/YPG.0000000000000003
Brief Reports

A potential approach for identification of candidate genes for depression is characterization of chromosomal rearrangements. Through analysis of a chromosome translocation in an individual with recurrent depression, we identified a potential candidate gene: the norepinephrine transporter (NET; SLC6A2 for solute carrier 6 family member 2). The gene is responsible for the reuptake of norepinephrine and dopamine into presynaptic nerve terminals and the norepinephrine system appears to play an important role in depression. We therefore analyzed genetic variants within SLC6A2 for association with depression in 408 affected and 559 control individuals from Denmark. After quality control of the genotypes, 31 of 45 single nucleotide polymorphisms (SNPs) were left for analyses. One SNP showed a nominal association with depression but did not survive correction for multiple testing. The results from our study do not suggest SLC6A2 as a susceptibility gene for depression in the Danish population.

aDepartment of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital

bTranslational Neuropsychiatry Unit, Department of Clinical Medicine

cDepartment of Biomedicine

dThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, PSYCH, Aarhus University, Aarhus

eNational Research Centre for the Working Environment

fDepartment of Occupational and Environmental Medicine, Bispebjerg University Hospital

gDepartment of Public Health

hPsychiatric Center Copenhagen, Mental Health Services in Capital Region

iDepartment of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen

jCenter for National Clinical Databases South, Odense University Hospital, Odense

kKennedy Center, Applied Human Molecular Genetics, Glostrup

lResearch Department P, Aarhus University Hospital, Risskov, Denmark

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Correspondence to Henriette N. Buttenschøn, PhD, Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Skovagervej 2, 8240 Risskov, Aarhus, Denmark Tel: +45 7847 1163; fax: +45 7847 1108; e-mail: henrbutt@rm.dk

Received August 9, 2012

Accepted January 14, 2013

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins