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Psychiatric Genetics:
doi: 10.1097/YPG.0b013e3283631509
Brief Report

No association between MspI allele of the ADRA2A polymorphism and ADHD: meta-analysis of family-based studies

Shiffrin, Nina D.a; Gruber, Junea; Glatt, Stephen J.b; Faraone, Stephen V.b

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Abstract

There is evidence for a genetic contribution to attention-deficit hyperactivity disorder (ADHD), although no candidate genes have attained genome-wide significance to date. Given that the noradrenergic system has been implicated in ADHD, the gene for the α2-adrenergic receptor (ADRA2A) has been hypothesized to contribute to the pathogenesis of ADHD. The present investigation reports results from a meta-analysis of family-based studies that did not find a significant association between the MspI polymorphism of the ADRA2A gene and ADHD.

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