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No association between genetic polymorphisms of the NDUFS7 gene and schizophrenia in Han Chinese

Ma, Lianga,c; Zhang, Wena,c; Tang, Jinsongb; Tan, Liwenb; Yao, Yong-Ganga; Chen, Xiaogangb

doi: 10.1097/YPG.0b013e32835862c5
Brief Reports

Accumulating evidence suggests that mitochondrial dysfunction contributes toward the pathogenesis of psychiatric diseases. NADH dehydrogenase Fe-S protein 7 (NDUFS7), a subunit of respiratory chain complex I, has been reported recently to be associated with bipolar disorder. To test whether this gene can confer a wide variety of psychiatric disorders, we carried out a case–control association analysis of three tagging single-nucleotide polymorphisms (rs2074896, rs2074897, and rs2074898) in the NDUFS7 gene by sequencing 330 Han Chinese patients with schizophrenia and 330 well-matched healthy controls. We found no significant difference in the frequency distributions of alleles, genotypes, and haplotypes between the cases and the controls, indicating no active role of this gene in schizophrenia.

aKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan

bInstitute of Mental Health the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China

cGraduate University of the Chinese Academy of Sciences, Beijing, China

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Correspondence to Yong-Gang Yao, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China Tel:/fax: +86-871-5180085; e-mail: ygyaozh@gmail.com

Received May 12, 2011

Accepted April 16, 2012

© 2013 Lippincott Williams & Wilkins, Inc.