Psychiatric Genetics

Skip Navigation LinksHome > August 2012 - Volume 22 - Issue 4 > The association of rs4307059 and rs35678 markers with autism...
Psychiatric Genetics:
doi: 10.1097/YPG.0b013e32835185c9
Original Articles

The association of rs4307059 and rs35678 markers with autism spectrum disorders is replicated in Italian families

Prandini, Paolaa; Pasquali, Alessandraa; Malerba, Giovannia; Marostica, Andreaa; Zusi, Chiaraa; Xumerle, Lucianoa; Muglia, Pierandreab; Da Ros, Luciob; Ratti, Emiliangelob; Trabetti, Elisabettaa; Pignatti, Pier Francoa; The Italian Autism Network (ITAN)

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Abstract

Objective: The objective of this study was to replicate an association study on a newly collected Italian autism spectrum disorder (ASD) cohort by studying the genetic markers associated with ASDs from recent genome-wide and candidate gene association studies.

Methods: We have genotyped 746 individuals from 227 families of the Italian Autism Network using allelic discrimination TaqMan assays for seven common single-nucleotide polymorphisms: rs2292813 (SLC25A12 gene), rs35678 (ATP2B2 gene), rs4307059 (between CDH9 and CDH10 genes), rs10513025 (between SEMA5A and TAS2R1 genes), rs6872664 (PITX1 gene), rs1861972 (EN2 gene), and rs4141463 (MACROD2 gene). A family-based association study was conducted.

Results: A significant association was found for two of seven markers: rs4307059 T allele (odds ratio: 1.758, SE=0.236; P-value=0.017) and rs35678 TC genotype (odds ratio: 0.528, SE=0.199; P-value=0.0013).

Conclusion: A preferential allele transmission of two markers located at loci previously associated with social and verbal communication skill has been confirmed in patients of a new ASD family sample.

© 2012 Lippincott Williams & Wilkins, Inc.

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