Psychiatric Genetics

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Psychiatric Genetics:
doi: 10.1097/YPG.0b013e328353953c
Brief Reports

No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia

Nyegaard, Mettea,c; Demontis, Dittec; Thestrup, Britta Boserupc; Hedemand, Annec; Sørensen, Karina Medene; Hansen, Thomasf; Werge, Thomasf; Hougaard, David Michaele; Yolken, Robert H.g; Mortensen, Preben Bod; Mors, Oleb; Børglum, Anders D.c,b

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Abstract

The human endogenous retrovirus HERV-K18 is located within intron 1 of CD48 on chromosome 1q and is still active in the human genome. Genetic variation in HERV-K18 single-nucleotide polymorphisms (SNPs) has previously been associated with an increased risk of schizophrenia (SZ) and with type 2 diabetes (T2D) among individuals with SZ. Here, we present a replication study of association of two SNPs in HERV-K18 and 19 tagSNPs in CD48 with (a) SZ and (b) T2D in patients with SZ in two Danish samples (total number of cases=750 and controls=1214). No association was found with SZ or with T2D among individuals with SZ for any of the investigated SNPs. However, one HERV-K18 SNP showed a tendency toward an association with T2D in younger SZ patients, in agreement with previous findings, but due to a very low sample size, this result needs to be further investigated.

© 2012 Lippincott Williams & Wilkins, Inc.

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