Psychiatric Genetics

Skip Navigation LinksHome > June 2012 - Volume 22 - Issue 3 > Anorexia nervosa and the Val158Met polymorphism of the COMT...
Psychiatric Genetics:
doi: 10.1097/YPG.0b013e328351859e
Original Articles

Anorexia nervosa and the Val158Met polymorphism of the COMT gene: meta-analysis and new data

Brandys, Marek K.a,d; Slof-Op’t Landt, Margarita C.T.e,f,i; van Elburg, Annemarie A.c,d; Ophoff, Roelb,l; Verduijn, Willemg; Meulenbelt, Ingridf; Middeldorp, Christel M.i,j,k; Boomsma, Dorret I.i; van Furth, Eric F.e; Slagboom, Elinef,h; Kas, Martien J. H.a; Adan, Roger A.H.a,d

Supplemental Author Material
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Objectives: This study aimed to test the association between the Val158Met polymorphism (rs4680) of the catechol-O-methyl transferase gene and anorexia nervosa (AN).

Methods: First, an association study on two cohorts (306 cases and 1009 controls from Utrecht, and 174 cases and 466 controls from Leiden/NTR) was performed. Subsequently, the results were integrated into a meta-analysis, together with all the case–control and family-based studies, which were testing the same hypothesis and were available in the literature. Altogether, eight studies (11 datasets) were included in this meta-analysis, with a total of 2021 cases, 2848 controls, and 89 informative (heterozygous) trios.

Results: The present association studies found no association between AN and rs4680 when testing the allelic contrast [Utrecht odds ratio (OR)=1.14, P=0.14; Leiden OR=1.02, P=0.85]. There was an indication of an association under the dominant model of genetic effect in the Utrecht cohort (for the Met allele, OR=1.42, P=0.03). Nevertheless, the meta-analyses of both the allelic contrast and the dominant effect were nonsignificant (the allelic pooled OR=1.03, P=0.42 and the dominant pooled OR=1.1, P=0.18). The meta-analyses were performed under the fixed-effect model and there was no significant heterogeneity among the effect sizes.

Conclusion: Meta-analytically combined evidence from the present genotypings and the literature search shows that the effect sizes are homogeneous across studies and that rs4680 is not associated with AN.

© 2012 Lippincott Williams & Wilkins, Inc.


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