Psychiatric Genetics

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Psychiatric Genetics:
doi: 10.1097/YPG.0b013e3283463deb
Brief Reports

Copy number variations in affective disorders and meta-analysis

Olsen, Linea,b; Hansen, Thomasa,b; Djurovic, Srdjane,f; Haastrup, Evac; Albrecthsen, Andersb; Hoeffding, Louise K.E.a; Secher, Annaa,b; Gustafsson, Omare,f; Jakobsen, Klaus D.a,b; Nielsen, Finn C.d; Ullum, Henrikc; Morken, Gunnarh; Agartz, Ingridf,g; Melle, Ingride,f; Gether, Ulrikb; Andreassen, Ole A.e,f; Werge, Thomasa

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In two recent studies 10 copy number variants (CNV) were found to be overrepresented either among patients suffering from affective disorders in an Amish family or in the Wellcome Trust Case–Control Consortium study. Here, we investigate if these variants are associated with affective disorders in a combined analysis of three case–control samples from Denmark, Norway and Iceland. A total of 1897 cases (n=1223 unipolar and n=463 bipolar) and 11 231 controls were analyzed for CNVs at the 10 genomic loci, but we found no combined association between these CNVs and affective disorders.

© 2011 Lippincott Williams & Wilkins, Inc.


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