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Copy number variations in affective disorders and meta-analysis

Olsen, Linea,b; Hansen, Thomasa,b; Djurovic, Srdjane,f; Haastrup, Evac; Albrecthsen, Andersb; Hoeffding, Louise K.E.a; Secher, Annaa,b; Gustafsson, Omare,f; Jakobsen, Klaus D.a,b; Nielsen, Finn C.d; Ullum, Henrikc; Morken, Gunnarh; Agartz, Ingridf,g; Melle, Ingride,f; Gether, Ulrikb; Andreassen, Ole A.e,f; Werge, Thomasa

doi: 10.1097/YPG.0b013e3283463deb
Brief Reports

In two recent studies 10 copy number variants (CNV) were found to be overrepresented either among patients suffering from affective disorders in an Amish family or in the Wellcome Trust Case–Control Consortium study. Here, we investigate if these variants are associated with affective disorders in a combined analysis of three case–control samples from Denmark, Norway and Iceland. A total of 1897 cases (n=1223 unipolar and n=463 bipolar) and 11 231 controls were analyzed for CNVs at the 10 genomic loci, but we found no combined association between these CNVs and affective disorders.

aInstitute for Biological Psychiatry, Mental Health Centre Sct. Hans, Roskilde

bMolecular Neuropharmacology Group and Center for Pharmacogenomics, Department of Neuroscience and Pharmacology, Copenhagen N

cDepartments of Clinical Immunology

dClinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

eTOP-project, Departments of Molecular Genetics and Psychiatry, Oslo University Hospital

fInstitute of Psychiatry, University of Oslo

gDepartment of Psychiatric Research, Diakonhjemmet Hospital, Oslo

hOestmarka Psychiatric Department, St Olavs Hospital and Institute of Neuroscience, Norwegian University of Technology and Science, Trondheim, Norway

Correspondence to Thomas Hansen, MSc, PhD, Research Institute for Biological Psychiatry, Copenhagen University Hospital, Psychiatric Centre Sct. Hans, Boserupvej 2, Roskilde DK-4000, Denmark Tel: +45 4633 4953; fax: +45 4633 4367; e-mail: thomas.hansen@regionh.dk

Line Olsen and Thomas Hansen have contributed equally to this study

Received September 6, 2010

Accepted February 22, 2011

© 2011 Lippincott Williams & Wilkins, Inc.