Psychiatric Genetics

Skip Navigation LinksHome > October 2011 - Volume 21 - Issue 5 > Thyroid-stimulating hormone, 5-HTTLPR genotype, and antidepr...
Psychiatric Genetics:
doi: 10.1097/YPG.0b013e3283457be5
Brief Reports

Thyroid-stimulating hormone, 5-HTTLPR genotype, and antidepressant response in depressed women

Gressier, Florencea; Trabado, Séverineb; Verstuyft, Célinec; Bouaziz, Elodiec; Hardy, Patricka; Fève, Brunod; Becquemont, Laurentc; Corruble, Emmanuellea

Collapse Box

Abstract

Basal serum thyroid-stimulating hormone (TSH) levels may predict antidepressant efficacy in patients with major depressive episodes (MDE), but data are inconsistent. As the SS genotype of the 5-HTTLPR polymorphism has been associated with a lower antidepressant efficacy in women with MDE, we aimed at assessing the relationship between normal basal TSH, 5-HTTLPR, and antidepressant efficacy in women. A total of 71 women and 28 men, with normal baseline TSH serum levels, hospitalized for a MDE, were assessed for 5-HTTLPR genotypes and prospectively followed for short-term antidepressant efficacy. Women with SS genotype had higher TSH levels (P=0.002) and a worse antidepressant response (P=0.046) than the women with LL/LS genotype, whereas no significant difference was shown in men. In multivariate analyses, antidepressant response in women was explained by TSH and 5-HTTLPR, but not by other variables. Further research is needed to understand the underlying mechanism explaining interactions between sex, TSH, and serotonergic function.

© 2011 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.