Psychiatric Genetics

Skip Navigation LinksHome > October 2011 - Volume 21 - Issue 5 > Thyroid-stimulating hormone, 5-HTTLPR genotype, and antidepr...
Psychiatric Genetics:
doi: 10.1097/YPG.0b013e3283457be5
Brief Reports

Thyroid-stimulating hormone, 5-HTTLPR genotype, and antidepressant response in depressed women

Gressier, Florencea; Trabado, Séverineb; Verstuyft, Célinec; Bouaziz, Elodiec; Hardy, Patricka; Fève, Brunod; Becquemont, Laurentc; Corruble, Emmanuellea

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Basal serum thyroid-stimulating hormone (TSH) levels may predict antidepressant efficacy in patients with major depressive episodes (MDE), but data are inconsistent. As the SS genotype of the 5-HTTLPR polymorphism has been associated with a lower antidepressant efficacy in women with MDE, we aimed at assessing the relationship between normal basal TSH, 5-HTTLPR, and antidepressant efficacy in women. A total of 71 women and 28 men, with normal baseline TSH serum levels, hospitalized for a MDE, were assessed for 5-HTTLPR genotypes and prospectively followed for short-term antidepressant efficacy. Women with SS genotype had higher TSH levels (P=0.002) and a worse antidepressant response (P=0.046) than the women with LL/LS genotype, whereas no significant difference was shown in men. In multivariate analyses, antidepressant response in women was explained by TSH and 5-HTTLPR, but not by other variables. Further research is needed to understand the underlying mechanism explaining interactions between sex, TSH, and serotonergic function.

© 2011 Lippincott Williams & Wilkins, Inc.


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