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Psychiatric Genetics:
doi: 10.1097/YPG.0b013e32834371fd
Brief Reports

Nonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power

Derringer, Jaimea; Krueger, Robert F.a; Manz, Niklasb; Porjesz, Berniceb; Almasy, Laurac; Bookman, Ebonyd; Edenberg, Howard J.e; Kramer, John R.f; Tischfield, Jay A.g; Bierut, Laura J.h

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Abstract

A recent study in a sample of Plains Indians showed association between eight single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and resting θ electroencephalogram (EEG) power. This association appeared to generalize to alcohol use disorders, for which EEG power is a potential endophenotype. We analyzed a large, diverse sample for replication of the association of these implicated SGIP1 SNPs (genotyped on the Illumina 1M platform) with alcohol dependence (N=3988) and θ EEG power (N=1066). We found no evidence of association of the earlier implicated SGIP1 SNPs with either alcohol dependence or θ EEG power (all P>0.15) in this sample. The earlier implicated SNPs located in SGIP1 gene showed no association with alcohol dependence or θ EEG power in this sample of individuals with European and/or African ancestry. This failure to replicate may be the result of differences in ancestry between this sample and the original sample.

© 2011 Lippincott Williams & Wilkins, Inc.

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