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Effect of ADRA2A and BDNF gene–gene interaction on the continuous performance test phenotype

Cho, Soo-Churla; Kim, Jae-Wona; Kim, Hyo-Wonb; Kim, Boong-Nyuna; Shin, Min-Supa; Cho, Dae-Yeonc; Jung, Sun-Wooa; Chung, Un-Sund; Son, Jung-Wooe

doi: 10.1097/YPG.0b013e328341a389
Brief Report

Complex phenotypes such as performance on the continuous performance test (CPT) are likely to exhibit epistasis. Genetic polymorphisms of noradrenergic system and brain-derived neurotrophic factor (BDNF), which participates in the differentiation and survival of noradrenergic neurons, have been reported to be associated with the performance on CPT. We evaluated the effect of the adrenergic α-2A receptor (ADRA2A) and BDNF gene–gene interaction on performance on the CPT in a Korean population with attention-deficit/hyperactivity disorder. In all, 122 participants with attention-deficit/hyperactivity disorder (8.6±2.3 years, 104 boys and 18 girls) completed the CPT. The DraI polymorphism of ADRA2A (rs583668) and rs11030101 polymorphism of BDNF were genotyped. Significant interaction effect was found of ADRA2A rs553668 and BDNF rs11030101 on response time variability (P=0.011) of the CPT. Our study provides preliminary evidence for the effect of the BDNF and ADRA2A gene–gene interaction on performance on the CPT in attention-deficit/hyperactivity disorder.

aDivision of Child and Adolescent Psychiatry, Department of Neuropsychiatry, Seoul National University College of Medicine

bDepartment of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center

cLabGenomics Clinical Research Institute, LabGenomics, Seoul

dDepartment of Psychiatry, Kyungpook National University Hospital, Daegu

eDepartment of Psychiatry, Chungbuk National University Hospital, Cheongju, Korea

Correspondence to Hyo-Won Kim MD, PhD, Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Pungnap-2-Dong, Songpa-Gu, Seoul 138-736, Korea Tel: +82 2 30103414; fax: +82 2 4858381; e-mail: shingubi@gmail.com

The results of this study were presented in the 56th annual meeting of the American Academy of Child and Adolescent Psychiatry.

Received January 24, 2010

Accepted September 22, 2010

© 2011 Lippincott Williams & Wilkins, Inc.