Psychiatric Genetics

Skip Navigation LinksHome > June 2011 - Volume 21 - Issue 3 > Dual association of a TRKA polymorphism with schizophrenia
Psychiatric Genetics:
doi: 10.1097/YPG.0b013e3283437194
Original Articles

Dual association of a TRKA polymorphism with schizophrenia

Van Schijndel, Jessica E.a; Van Zweeden, Martinea; Van Loo, Karen M.J.a; Djurovic, Srdjanb; Andreassen, Ole A.b,c,d; Hansen, Thomase; Werge, Thomase; Nyegaard, Mettef,k,h; Sørensen, Karina Medenj; Nordentoft, Meretek; Mortensen, Preben B.g; Mors, Olei; Børglum, Anders D.f,i; Del-Favero, Jurgenm,n; Norrback, Karl-Fredrikn,q,r; Adolfsson, Rolfq,r; Hert, Marc Deo; Claes, Stephanp; Cichon, Svens,t,u; Rietschel, Marcellav; Nöthen, Markus M.s,u; Kallunki, Pekkal; Pedersen, Jan T.l; Martens, Gerard J.M.a

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Abstract

Objective: An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with schizophrenia as a risk factor.

Methods: We genotyped the TRKA SNP in a total of eight independent Caucasian schizophrenia case–control groups.

Result: Remarkably, although in five of the groups a higher frequency of the risk allele was indeed found in the patients compared with the controls, in the three other groups the SNP acted as a protective factor.

Conclusion: An intriguing possibility is that this dual character of the TRKA SNP is caused by its interaction with endophenotypic and/or epistatic factors.

© 2011 Lippincott Williams & Wilkins, Inc.

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