Skip Navigation LinksHome > April 2011 - Volume 21 - Issue 2 > Database of genetic studies of bipolar disorder
Text sizing:
A
A
A
Psychiatric Genetics:
doi: 10.1097/YPG.0b013e328341a346
Review Articles

Database of genetic studies of bipolar disorder

Piletz, John E.a; Zhang, Xiaotongb; Ranade, Rajdeepa; Liu, Chunyub

Collapse Box

Abstract

This study describes the construction and preliminary analysis of a database of summary level genetic findings for bipolar disorder from the literature. The database is available for noncommercial use at http://bioprogramming.bsd.uchicago.edu/BDStudies/. This may be the first complete collection of published gene-specific linkage and association findings on bipolar disorder, including genome-wide association studies. Both the positive and negative findings have been incorporated so that the statistical and contextual significance of each finding may be compared semi-quantitatively and qualitatively across studies of mixed technologies. The database is appropriate for searching a literature populated by mainly underpowered studies, and if ‘hits’ are viewed as tentative knowledge for future hypothesis generation. It can serve as the basis for a mega-analysis of candidate genes. Herein, we discuss the most robust and best replicated gene findings to date in a contextual manner.

© 2011 Lippincott Williams & Wilkins, Inc.

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.