This study describes the construction and preliminary analysis of a database of summary level genetic findings for bipolar disorder from the literature. The database is available for noncommercial use at http://bioprogramming.bsd.uchicago.edu/BDStudies/. This may be the first complete collection of published gene-specific linkage and association findings on bipolar disorder, including genome-wide association studies. Both the positive and negative findings have been incorporated so that the statistical and contextual significance of each finding may be compared semi-quantitatively and qualitatively across studies of mixed technologies. The database is appropriate for searching a literature populated by mainly underpowered studies, and if ‘hits’ are viewed as tentative knowledge for future hypothesis generation. It can serve as the basis for a mega-analysis of candidate genes. Herein, we discuss the most robust and best replicated gene findings to date in a contextual manner.
aDepartment of Psychiatry, Loyola University of Chicago, Stritch School of Medicine, Maywood
bDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA
Correspondence to John E. Piletz, PhD, Department of Psychiatry, Loyola University Chicago, Stritch School of Medicine, 2160 South First Avenue, Building 105, Room 1940, Maywood, IL 60153, USA Tel: +1 708 216 3276; fax: +1 708 216 5885; e-mail: email@example.com
Received February 27, 2010
Accepted June 29, 2010