Objective: Bipolar disorder is a common, severe, and recurrent psychiatric disorder. The Disrupted in Schizophrenia 1 (DISC1) gene has been associated with the risk of schizophrenia, schizoaffective disorder, bipolar disorder, major depression, autism, and Asperger syndrome in different populations. Here, we report the first association study for the DISC1 with bipolar disorder in Chinese cohorts.
Methods: We conducted a case-control study and genotyped 12 single nucleotide polymorphisms in 506 bipolar patients and 507 controls recruited from Anhui province in China. The genotyping procedure was carried on the ABI 7900 DNA detection platform by using TaqMan probe technology.
Result: Although the data did not show association between any individual single nucleotide polymorphism in the DISC1 gene and bipolar disorder, a haplotype [rs2738864 (C)–rs16841582 (C)] was found to be associated with the disorder (P=0.0191).
Conclusion: This finding provides evidence supporting the role of DISC1 gene in bipolar disorder, and shows the presence of population heterogeneity.
bBio-X Life Science Center, Shanghai Jiao Tong University
cInstitutes of Biomedical Sciences, Fudan University
dInstitute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences
eShanghai Institute of Mental Health, Shanghai
fWuhu No. 4 People's Hospital, Jiulong, Matang District, Wuhu, People's Republic of China
Correspondence to Dr Lin He, Institutes of Biomedical Sciences Fudan University, 138 Yixueyuan Road, Shanghai 200032, People's Republic of China Tel/fax: +86 21 62822491; e-mail: email@example.comDr Guang He, Bio-X Center, Shanghai Jiao Tong University, Haoran Building, 1954 Huashan Road, Shanghai 200030, People's Republic of China Tel/fax: +86 21 62822491; e-mail: firstname.lastname@example.org
Received November 16, 2009
Accepted June 20, 2010