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Limited association between Disrupted in Schizophrenia 1 (DISC1) gene and bipolar disorder in the Chinese population

Xiao, Yuea,d; Zhang, Jinga,d; Wang, Yanga,d; Wang, Pengf; Li, Xingwanga,c,d; Ji, Juea,d; Yang, Fengpinga,d; Feng, Guoyine; He, Linb,c,d; He, Guanga,d

doi: 10.1097/YPG.0b013e32834135d2
Original Articles

Objective Bipolar disorder is a common, severe, and recurrent psychiatric disorder. The Disrupted in Schizophrenia 1 (DISC1) gene has been associated with the risk of schizophrenia, schizoaffective disorder, bipolar disorder, major depression, autism, and Asperger syndrome in different populations. Here, we report the first association study for the DISC1 with bipolar disorder in Chinese cohorts.

Methods We conducted a case-control study and genotyped 12 single nucleotide polymorphisms in 506 bipolar patients and 507 controls recruited from Anhui province in China. The genotyping procedure was carried on the ABI 7900 DNA detection platform by using TaqMan probe technology.

Result Although the data did not show association between any individual single nucleotide polymorphism in the DISC1 gene and bipolar disorder, a haplotype [rs2738864 (C)–rs16841582 (C)] was found to be associated with the disorder (P=0.0191).

Conclusion This finding provides evidence supporting the role of DISC1 gene in bipolar disorder, and shows the presence of population heterogeneity.

aBio-X Center

bBio-X Life Science Center, Shanghai Jiao Tong University

cInstitutes of Biomedical Sciences, Fudan University

dInstitute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences

eShanghai Institute of Mental Health, Shanghai

fWuhu No. 4 People's Hospital, Jiulong, Matang District, Wuhu, People's Republic of China

Correspondence to Dr Lin He, Institutes of Biomedical Sciences Fudan University, 138 Yixueyuan Road, Shanghai 200032, People's Republic of China Tel/fax: +86 21 62822491; e-mail: helinhelin@gmail.comorDr Guang He, Bio-X Center, Shanghai Jiao Tong University, Haoran Building, 1954 Huashan Road, Shanghai 200030, People's Republic of China Tel/fax: +86 21 62822491; e-mail: heguang@sjtu.edu.cn

Received November 16, 2009

Accepted June 20, 2010

© 2011 Lippincott Williams & Wilkins, Inc.