Psychiatric Genetics

Skip Navigation LinksHome > February 2011 - Volume 21 - Issue 1 > Case–case genome-wide association analysis shows markers dif...
Text sizing:
Psychiatric Genetics:
doi: 10.1097/YPG.0b013e3283413382
Original Articles

Case–case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes

Curtis, Davida; Vine, Anna E.a; McQuillin, Andrewb; Bass, Nicholas Jamesb; Pereira, Anab; Kandaswamy, Radhikab; Lawrence, Jacobb; Anjorin, Adebayob; Choudhury, Khalidb; Datta, Susmita R.b; Puri, Vinayb; Krasucki, Robertb; Pimm, Jonathanb; Thirumalai, Srinivasab; Quested, Digbyb; Gurling, Hugh M.D.b

Collapse Box


Objective: There are theoretical reasons why comparing marker allele frequencies between cases of different diseases, rather than with controls, may offer benefits. The samples may be better matched, especially for background risk factors common to both diseases. Genetic loci may also be detected which influence which of the two diseases occurs if common risk factors are present.

Method: We used samples of UK bipolar and schizophrenic cases that had earlier been subject to genome-wide association studies and compared marker allele frequencies between the two samples. When these differed for a marker, we compared the case sample allele frequencies with those of a control sample.

Results: Eight markers were significant at P value of less than 10−5. Of these, the most interesting finding was for rs17645023, which was significant at P value of less than 10−6 and which lies 36 kb from CACNG5. Control allele frequencies for this marker were intermediate between those for bipolar and schizophrenic cases.

Conclusion: The application of this approach suggests that it does have some merits. The finding for CACNG5, taken together with the earlier implication of CACNA1C and CACNA1B, strongly suggests a key role for voltage-dependent calcium channel genes in the susceptibility to bipolar disorder and/or schizophrenia.

© 2011 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.