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Glucocorticoid receptor gene polymorphisms in Italian patients with eating disorders and obesity

Cellini, Elenaa; Castellini, Giovannib; Ricca, Valdob; Bagnoli, Silviaa; Tedde, Andreaa; Rotella, Carlo Mariac; Faravelli, Carlod; Sorbi, Sandroa; Nacmias, Benedettaa

Psychiatric Genetics:
doi: 10.1097/YPG.0b013e32833a2142
Original Articles
Abstract

Objective: Glucocorticoids (GCs) are involved in the control of eating behaviors, and it has been proposed that GCs and their receptors (GR) could play a significant role in the pathophysiology of eating disorders (EDs) and obesity. We studied whether genetic variants, such as N363S (rs56149945), exon 9-β (rs6198), ER22/23EK (rs6189–6190), and the intronic BclI restriction site (rs41423247) polymorphisms in the GR gene, could be considered as risk factors for the development of EDs and obesity in Italian patients.

Methods: We investigated the distribution of these single nucleotide polymorphisms in 572 Italian patients: 118 patients with anorexia nervosa, 108 patients with bulimia nervosa, 62 patient with binge eating disorder, 177 obese non-binge eating disorder patients, and 107 unrelated, normal, age-matched controls. In addition, we analyzed their possible effects on body mass index and in relation to different psychopathological features.

Results: A significant association between the single nucleotide polymorphism rs56149945 (N363S) and a higher body mass index was identified, even after adjusting for age, sex, and diagnosis, independently of the eating psychopathology. Moreover, the rs6198 polymorphism was associated to binge eating symptoms, whereas no significant association between the different GR polymorphisms and the other ED diagnoses was observed.

Conclusion: Our results suggest the possible role of the GC system in the genetics of eating psychopathology, weight control, and energy balance in ED and obese patients.

Author Information

aDepartment of Neurological and Psychiatric Sciences, Neurology Unit

bDepartment of Neurological and Psychiatric Sciences, Psychiatry Unit, University of Florence, Viale Morgagni

cDepartment of Clinical Pathophysiology, Section of Metabolic Diseases and Diabetology, Endocrinology Unit, University of Florence, Viale Pieraccini

dDepartment of Psychology, Florence University, Via San Niccolò, Florence, Italy

Correspondence to Benedetta Nacmias, PhD, Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni, 85, 50134 Florence, Italy

Tel: +39 55 4271379; fax: +39 55 4271380; e-mail: nacmias@unifi.it

Received 10 June 2009 Revised 26 January 2010 Accepted 3 February 2010

© 2010 Lippincott Williams & Wilkins, Inc.