Psychiatric Genetics

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Psychiatric Genetics:
doi: 10.1097/YPG.0b013e32833a201d
Original Articles

Habituation in prepulse inhibition is affected by a polymorphism on the NMDA receptor 2B subunit gene (GRIN2B)

Hokyo, Akiraa b; Kanazawa, Tetsufumia b; Uenishi, Hiroyukib c; Tsutsumi, Atsushia f; Kawashige, Seiyaa g; Kikuyama, Hirokia e; Glatt, Stephen J.i; Koh, Juna; Nishimoto, Yoshiyukia b; Matsumura, Hitoshih; Motomura, Naoyasua d; Yoneda, Hiroshia

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Objectives: To identify the reliable connectivity between causal genes or variants with an abnormality expressed in a certain endophenotype has been viewed as a crucial step in unraveling the etiology of schizophrenia because of the considerable heterogeneity in this disorder.

Methods: According to this practical and scientific demand, we aimed to investigate the relationship between seven top-ranked variants in the SZgene database [120-bpTR in DRD4, rs1801028 and rs6277 in DRD2, rs1019385 (T200G) in GRIN2B, rs1800532 in TPH1, rs1801133 (C677T) in MTHFR, rs2619528 (P1765) in DTNBP1] and prepulse inhibition (PPI) and habituation after acoustic stimulus (HAB).

Results: Both PPI and HAB were decreased significantly in patients with schizophrenia. In addition, we observed a significant effect of GRIN2B (human NMDA receptor 2B subunit gene, NR2B) genotype on HAB (P<0.05, not corrected).

Conclusion: Although these findings need to be replicated in other samples, an underlying mechanism of impaired biological reaction may be influenced by NMDA hypofunctioning in schizophrenia.

© 2010 Lippincott Williams & Wilkins, Inc.


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