Psychiatric Genetics

Skip Navigation LinksHome > October 2010 - Volume 20 - Issue 5 > Habituation in prepulse inhibition is affected by a polymorp...
Text sizing:
Psychiatric Genetics:
doi: 10.1097/YPG.0b013e32833a201d
Original Articles

Habituation in prepulse inhibition is affected by a polymorphism on the NMDA receptor 2B subunit gene (GRIN2B)

Hokyo, Akiraa b; Kanazawa, Tetsufumia b; Uenishi, Hiroyukib c; Tsutsumi, Atsushia f; Kawashige, Seiyaa g; Kikuyama, Hirokia e; Glatt, Stephen J.i; Koh, Juna; Nishimoto, Yoshiyukia b; Matsumura, Hitoshih; Motomura, Naoyasua d; Yoneda, Hiroshia

Collapse Box


Objectives: To identify the reliable connectivity between causal genes or variants with an abnormality expressed in a certain endophenotype has been viewed as a crucial step in unraveling the etiology of schizophrenia because of the considerable heterogeneity in this disorder.

Methods: According to this practical and scientific demand, we aimed to investigate the relationship between seven top-ranked variants in the SZgene database [120-bpTR in DRD4, rs1801028 and rs6277 in DRD2, rs1019385 (T200G) in GRIN2B, rs1800532 in TPH1, rs1801133 (C677T) in MTHFR, rs2619528 (P1765) in DTNBP1] and prepulse inhibition (PPI) and habituation after acoustic stimulus (HAB).

Results: Both PPI and HAB were decreased significantly in patients with schizophrenia. In addition, we observed a significant effect of GRIN2B (human NMDA receptor 2B subunit gene, NR2B) genotype on HAB (P<0.05, not corrected).

Conclusion: Although these findings need to be replicated in other samples, an underlying mechanism of impaired biological reaction may be influenced by NMDA hypofunctioning in schizophrenia.

© 2010 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.