Aim: Apolipoprotein E (APOE) has been regarded as the principal susceptibility gene linked with Alzheimer's disease, also suggesting a relationship with depression in the elderly population. Thus, the purpose was to investigate the association of APOE polymorphisms with depression in elderly adults.
Methods: APOE polymorphisms were determined in a Mexican population-based sample older than 60 years (n=1566) using 5′ exonuclease TaqMan genotyping assays.
Results: The distribution of the APOE allele and genotype frequencies was similar in patients with and without depression. There was no significant association between the presence of alleles or genotypes and depression and anxiety (Short Anxiety Screening Test) considering several combinations of other features. However, patients with the APOE*4 allele presented more thinking and concentration impairment than those patients with the APOE*3 allele.
Conclusion: Genetic variation at the APOE gene may contribute to some depressive symptoms in late-onset depression, rather than being a specific risk factor.
aEpidemiologic and Health Service Research Unit, Aging Area, Instituto Mexicano del Seguro Social
bDepartment of Molecular Biology and Cardiovascular Disease's Genomic and Proteomic Study Group, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
cDepartment of Family Practice and Community Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
dDrug Abuse Research Program, Center for Health Disparities Solutions, School of Community Health and Policy, Morgan State University, Baltimore, Maryland, USA
Correspondence to Dr Gilberto Vargas-Alarcón, PhD, Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, C.P. 14050, México, D.F.
Tel: +5255 5573 29 11 x1461; fax: +5255 55 73 09 26;
Received 26 February 2009 Revised 18 November 2009 Accepted 1 January 2010