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No association between DGKH and bipolar disorder in a Scandinavian casecontrol sample

Tesli, Martina d; Kähler, Anna K.a d e; Andreassen, Bettina Kulleb c; Werge, Thomasf; Mors, Oleg; Mellerup, Erlingh i; Koefoed, Pernilleh i; Melle, Ingrida d; Morken, Gunnarj k; Wirgenes, Katrine V.a d; Andreassen, Ole A.a d; Djurovic, Srdjana d e

Psychiatric Genetics:
doi: 10.1097/YPG.0b013e32832d302f
Brief Report
Abstract

Single nucleotide polymorphisms (SNPs) in diacylglycerol kinase eta (DGKH) have recently been shown to be associated with bipolar disorder (BD). To replicate this finding, we carried out a gene-wide genotyping of 36 tagSNPs in DGKH and performed a population-based association study on two Scandinavian samples, with successful genotyping of 594 BD cases and 1421 healthy controls. We found no significant association after multiple-testing correction between any of these SNPs and BD in our sample. Thus, it is unlikely that these genetic variations confer susceptibility to BD in this large Scandinavian sample.

Author Information

aInstitute of Psychiatry

bEpi-Gen, Faculty Division Akershus University Hospital

cDepartment of Biostatistics, University of Oslo

dDepartments of Psychiatry

eMedical Genetics, Oslo University Hospital, Ullevål, Oslo

fResearch Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Copenhagen University Hospital

gCenter for Psychiatric Research, Aarhus University Hospital, Risskov

hCenter of Psychiatry, Rigshospitalet, Copenhagen

iLaboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology, University of Copenhagen, Denmark

jØstmarka Psychiatric Department, St. Olavs Hospital, Trondheim, Norway

kInstitute of Neuroscience, Norwegian University of Technology and Science, Trondheim, Norway

Correspondence to Martin Tesli, MD, Section for Psychosis Research, Building 49, Division of Psychiatry, Department for Research and Development, Oslo University Hospital, Ullevål, Kirkeveien 166, N-0407 Oslo, Norway

Tel: +47 22116277; fax: +47 23027332; e-mail: m.s.tesli@medisin.uio.no

Received 7 January 2009 Revised 23 March 2009 Accepted 20 April 2009

© 2009 Lippincott Williams & Wilkins, Inc.