Psychiatric Genetics

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Psychiatric Genetics:
doi: 10.1097/YPG.0b013e32832d302f
Brief Report

No association between DGKH and bipolar disorder in a Scandinavian case–control sample

Tesli, Martina d; Kähler, Anna K.a d e; Andreassen, Bettina Kulleb c; Werge, Thomasf; Mors, Oleg; Mellerup, Erlingh i; Koefoed, Pernilleh i; Melle, Ingrida d; Morken, Gunnarj k; Wirgenes, Katrine V.a d; Andreassen, Ole A.a d; Djurovic, Srdjana d e

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Abstract

Single nucleotide polymorphisms (SNPs) in diacylglycerol kinase eta (DGKH) have recently been shown to be associated with bipolar disorder (BD). To replicate this finding, we carried out a gene-wide genotyping of 36 tagSNPs in DGKH and performed a population-based association study on two Scandinavian samples, with successful genotyping of 594 BD cases and 1421 healthy controls. We found no significant association after multiple-testing correction between any of these SNPs and BD in our sample. Thus, it is unlikely that these genetic variations confer susceptibility to BD in this large Scandinavian sample.

© 2009 Lippincott Williams & Wilkins, Inc.

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