Recently, an association of the Val66Met polymorphism of the brain-derived neurotrophic factor with hippocampal volume in patients with major depression has been reported. Here, we aimed at replicating this finding in an independent German sample. We included 79 patients with unipolar major depressive episodes and 84 healthy comparison participants. The brain-derived neurotrophic factor Val66Met polymorphism was determined in all participants. The volume of the hippocampus was manually traced on high-resolution magnetic resonance images. The hippocampal volumes of patients were significantly smaller than those of the comparison participants, confirming previous reports. There was, however, no Val66Met effect on hippocampal volume in either group. To conclude, we did not replicate the Val66Met effect on hippocampal volume in neither patients with major depression nor in healthy participants.
Departments of aPsychiatry
bRadiology, University of Bonn, Germany
Correspondence to Frank Jessen, MD, Department of Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, Bonn 53105, Germany
Tel: +49 228 287 11109; fax: +49 228 287 16097;
Received 13 June 2008 Revised 25 August 2008 Accepted 25 August 2008