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Sequence analysis of the complete SLITRK1 gene in Austrian patients with Tourette's disorder

Zimprich, Alexandera; Hatala, Katharinaa; Riederer, Franza; Stogmann, Elisabetha; Aschauer, Harald N.b; Stamenkovic, Marab

Psychiatric Genetics:
doi: 10.1097/YPG.0b013e3283060f6f
Brief Reports
Abstract

Mutations in the gene SLITRK1 (Slit and Trk-like 1) have been reported in patients with Tourette's disorder (TD). We sequenced the entire SLITRK1 gene including the coding region the 5′ and 3′ untranslated region in 92 Austrian patients with TD. No nucleotide changes within the protein-coding region were identified. One patient was found to carry a variant within the 3′ untranslated region (3383g>a), which was absent in 192 control individuals and which segregated in two additional family members with tic symptoms. In conclusion, our results provide no evidence for SLITRK1 playing a major role in TD.

Author Information

aDepartment of Neurology

bDepartment of Psychiatry and Psychotherapy, Clinical Department of Biological Psychiatry, Medical University of Vienna, Austria

Correspondence to Alexander Zimprich, Medical University of Vienna, Department of Neurology, Allgemeines Krankenhaus der Stadt Wien, Waehringer Guertel 18-20, Vienna A-1090, Austria

Tel: +43 1 40 400 6349; fax: +43 1 40 400 3141;

e-mail: alexander.zimprich@meduniwien.ac.at

Received 6 August 2007 Revised 21 January 2008 Accepted 9 March 2008

© 2008 Lippincott Williams & Wilkins, Inc.