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Psychiatric Genetics:
doi: 10.1097/YPG.0b013e3280c1e5de
Original Articles

Study on the interrelationship between 5-HTTLPR/G-protein β3 subunit (C825T) polymorphisms and depressive disorder

Cao, Mei-Quna; Hu, Sui-Yua; Zhang, Chun-Hua; Xia, Da-Shengb

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Abstract

Objective: To assess whether the promoter region of the serotonin transporter gene (5-HTTLPR) and G-protein β3-subunit (GNβ3 C825T) polymorphisms are associated with depressive disorder and explore the genetic mechanism concerning the pathogenesis of this disorder.

Methods: The genotypes were determined with polymerase chain reaction and allele-specific restriction enzyme analysis. Patients suffering from depression (n=184) and sex and age-matched controls (n=158) were compared in this study.

Results: The frequencies of 5-HTTLPR SS and GNβ3 825TT genotypes and 5-HTTLPR S and GNβ3 825T alleles in patients suffering from depression were significantly higher than those in the controls (P<0.01). Combined genotype analysis showed that individuals with both 5-HTTLPR S and GNβ3 825T alleles (odds ratio=3.25, P=0.002) had a risk of depressive disorder higher than those with 5-HTTLPR S (odds ratio=1.817, P=0.01) or GNβ3 825T alleles (odds ratio=2.214, P=0.001) alone.

Conclusions: These results indicated that the etiology of depressive disorder is associated with 5-HTTLPR and GNβ3 C825T polymorphisms. Our data also suggests that an interaction effect may exist between the 5-HTTLPR S allele and GNβ3 825T allele in increasing the risk of depressive disorder.

© 2007 Lippincott Williams & Wilkins, Inc.

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