Psychiatric Genetics

Skip Navigation LinksHome > August 2007 - Volume 17 - Issue 4 > Case–control and within-family tests for association between...
Text sizing:
A
A
A
Psychiatric Genetics:
doi: 10.1097/YPG.0b013e32809913c8
Original Articles

Case–control and within-family tests for association between 5HTTLPR and conduct problems in a longitudinal adolescent sample

Sakai, Joseph T.a; Lessem, Jeff M.b; Haberstick, Brett C.b; Hopfer, Christian J.a; Smolen, Andrewb; Ehringer, Marissa A.b; Timberlake, Davidb c; Hewitt, John K.b

Collapse Box

Abstract

Background: Several recent studies have reported an association between the serotonin transporter 5HTTLPR (s-allele) and aggression; however, nonreplications have also been reported. Inconsistencies may be explained by gene–environment interactions. Using a large general population sample, we sought to test for an association between 5HTTLPR and conduct problems, and to explore for a possible 5HTTLPR by maltreatment interaction.

Methods: Using Caucasian adolescents from the genetic-pairs sample of the National Longitudinal Study of Adolescent Health (n=1736), we tested for an association between 5HTTLPR and both a categorical and, separately, a continuous measure of conduct problems using regression analyses while controlling for sex, family effects, and age. We then tested for an association between 5HTTLPR and conduct problems using the within-family test Quantitative Transmission Disequilibrium Test. Analyses were repeated for a measure of adolescence-limited delinquency.

Results: Results did not support an association between 5HTTLPR and conduct problems or delinquency. The Quantitative Transmission Disequilibrium Test analyses, which account for population stratification, were nonsignificant (F=0.17; P=0.68); introducing maltreatment as a covariate into the model did not affect this association (F=0.17; P=0.68). No association was seen between 5HTTLPR and a measure of adolescence-limited delinquency (F=0.54; P=0.46).

Discussion: Using two methods in a large general population sample we did not find a significant association between 5HTTLPR and conduct problems. A gene by maltreatment interaction was not supported.

© 2007 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.