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The nitric oxide synthase-3 codon 298 polymorphism is not associated with late-onset sporadic Alzheimer's dementia and Lewy body disease in a sample from Hungary

Kálmán, Jánosa; Juhász, Annaa; Rimanóczy, Ágnesa; Palotás, Andrásb; Palotás, Miklósc; Boda, Krisztinad; Márki-Zay, Jánose; Csibri, Évaf; Janka, Zoltána

Psychiatric Genetics:
Original Articles
Abstract

An association study was performed between apolipoprotein E (apoE) polymorphism and the common structural polymorphism Glu/Asp at codon 298 of the nitric oxide synthase (NOS3) gene in late-onset sporadic Alzheimer's dementia probands (LOAD), diffuse Lewy body dementia cases (DLBD) and controls in a Hungarian sample. The frequency of individuals who carried the apoE &epsiv;4 allele was significantly more common in both dementia groups (LOAD, 20%; DLBD, 27%; control, 8%; control versus DLBD, χ2=13.264, degrees of freedom=2, P<0.001; control versus LOAD, χ2=6.628, degrees of freedom=2, P<0.036). However, there were no significant differences in the NOS3 genotype and allele distributions between the LOAD, DLBD and control groups. The apoE status has been found to be independent from the NOS3 codon 298 polymorphism in the examined cohort. Despite the facts that NOS3 is associated with neuritic sprouting, and aberrant neuronal and glial expression of the same molecule has been found in neurodegenerative diseases, it is unlikely that the polymorphism Glu/Asp of the NOS3 gene is involved in the development of LOAD and DLBD.

Author Information

aDepartment of Psychiatry

bDepartment of Surgery

cDepartment of Intensive Care and Anesthesiology

dDepartment of Medical Informatics, Albert Szent-Györgyi Center for Medical and Pharmaceutical Sciences, Faculty of Medicine, University of Szeged, Szeged, Hungary

eCentral Laboratory, Békés County Hospital, Gyula, Hungary

fDepartment of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary

Sponsorship: This work was supported by a grant from the Health Scientific Board (ETT 01817/2000), Hungary.

Correspondence and requests for reprints to János Kálmán, Department of Psychiatry, Albert Szent-Györgyi Center for Medical and Pharmaceutical Sciences, Faculty of Medicine, University of Szeged, Semmelweis u.6., H-6725 Szeged, Hungary

Tel: +36 62 545360; fax: +36 62 545 973;

e-mail address: kalmanj@nepsy.szote.u-szeged.hu

Received 7 April 2002 Accepted 7 February 2003

© 2003 Lippincott Williams & Wilkins, Inc.