An association study was performed between apolipoprotein E (apoE) polymorphism and the common structural polymorphism Glu/Asp at codon 298 of the nitric oxide synthase (NOS3) gene in late-onset sporadic Alzheimer's dementia probands (LOAD), diffuse Lewy body dementia cases (DLBD) and controls in a Hungarian sample. The frequency of individuals who carried the apoE ϵ4 allele was significantly more common in both dementia groups (LOAD, 20%; DLBD, 27%; control, 8%; control versus DLBD, χ2=13.264, degrees of freedom=2, P<0.001; control versus LOAD, χ2=6.628, degrees of freedom=2, P<0.036). However, there were no significant differences in the NOS3 genotype and allele distributions between the LOAD, DLBD and control groups. The apoE status has been found to be independent from the NOS3 codon 298 polymorphism in the examined cohort. Despite the facts that NOS3 is associated with neuritic sprouting, and aberrant neuronal and glial expression of the same molecule has been found in neurodegenerative diseases, it is unlikely that the polymorphism Glu/Asp of the NOS3 gene is involved in the development of LOAD and DLBD.
aDepartment of Psychiatry
bDepartment of Surgery
cDepartment of Intensive Care and Anesthesiology
dDepartment of Medical Informatics, Albert Szent-Györgyi Center for Medical and Pharmaceutical Sciences, Faculty of Medicine, University of Szeged, Szeged, Hungary
eCentral Laboratory, Békés County Hospital, Gyula, Hungary
fDepartment of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary
Sponsorship: This work was supported by a grant from the Health Scientific Board (ETT 01817/2000), Hungary.
Correspondence and requests for reprints to János Kálmán, Department of Psychiatry, Albert Szent-Györgyi Center for Medical and Pharmaceutical Sciences, Faculty of Medicine, University of Szeged, Semmelweis u.6., H-6725 Szeged, Hungary
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Received 7 April 2002 Accepted 7 February 2003