Teenagers may experience physiological and psychological changes when they suffer from a severe burn. The aim of this study was to assess the state of health of teenagers who were undergoing a rehabilitation process following a severe burn. A cross-sectional field study was carried out with 63 teenagers and young adults who had suffered burns. The tests applied were social, demographic, and clinical instruments. The specific tests included the Burn Specific Health Scale–Revised, Beck Depression Inventory, Rosenberg's Self-Esteem Scale, and Functional Independence Measurement. The results were analyzed by using descriptive statistics, multivariate analysis of variance, variance analysis, and Cronbach's reliability analysis. The social and demographic analysis of the population has shown a prevalence of female (60.3%), single subjects (93.7%), and ages between 12 and 20 years (mean age of 15.95 years). The mean total body surface area burn was 23.84%, with accidents as the main causative factor (92.10%). More than half (52.4%) reported functional and aesthetic effects after the burn, with 81% concerned about the visible scar. Cronbach's reliability analysis has shown statistically confident results for all the instruments as applied. The multivariate analysis showed a correlation between the work domain and marital status, whereas there was no evidence to show a correlation between sex, age, physical or aesthetic sequelae or visibility of burns, and depression, self-esteem, functional independence, or current state of health. The results obtained prove the reliability of the instruments applied, making it possible to assess the state of teenagers and young adults health during the rehabilitation process.