PRS AAPS Oral Proofs 2016
Fabio Santanelli di Pompeo, MD, PhD, Benedetto Longo, MD, PhD, Rosaria Laporta, MD, PhD
From the Sapienza University, Rome, Italy.
PURPOSE: Rate of fat grafting take may depend on several issues including irradiated recipient beds. Its use in reconstruction of previously irradiated nipple-sparing mastectomy (NSM) needs further clarification.
METHODS: Between 2008 and 2014, 42 NSMs, mean weight of 358 g (range, 220-470 g; 29 patients), were prospectively enrolled in fat grafting reconstruction and stratified into group A (28 nonirradiated) and group B (14 irradiated). Fat tissue was dry harvested with 2/3 mm cannula and 10-ml syringe, centrifuged at 3000 rpm/3 minutes, and injected with a blunt cannula and 1-ml syringe in subcutaneous and submuscular layers. The injected fat volume for each session was equal to one third of the mastectomy weight. The rule of 30% more was applied from the second to the last session for the incomplete graft taking. Variables were analyzed using the Student t test and Kruskal-Wallis test considering P ≤ 0.05 as significant.
RESULTS: The 2 groups were homogeneous regarding demographics (P > 0.05), whereas number of sessions, mean volume of first 2 treatments, and overall injected showed significant difference (P = 0.003, P = 0.004, and P = 0.005, respectively). Volume, shape, breast mound position, inframammary fold, scar location subscales, and global score had high evaluation in both groups (P > 0.05), whereas skin texture and total subscales scored less in group B than in group A (P = 0.006 and P = 0.003).
CONCLUSIONS: The first prospective fat transfer reconstruction series, with systematic approach, showed overall pleasing aesthetic outcomes but needs more fat transfer sessions in irradiated NSMs.