Plastic and Reconstructive Surgery - Global Open:
Severe, Steroid-responsive, Myositis Mimicking Necrotizing Fasciitis following Orthopedic Surgery: A Pyoderma Variant with Myonecrosis
Reid, Alistair B. FRACP*†; Stanley, Peter FRACP‡; Grinsell, Damien FRACS§; Daffy, John R. FRACP‡
From the *Infectious Diseases Unit, Wollongong Hospital, NSW, Australia; †University of Wollongong, NSW, Australia; ‡Infectious Diseases Unit, St Vincent’s Hospital Melbourne, VIC, Australia; and §Plastic Surgery Department, St Vincent’s Hospital Melbourne, VIC, Australia.
Received for publication February 10, 2014; accepted April 29, 2014.
Disclosure: The authors have no financial interest to declare in relation to the content of this article. The Article Processing Charge was paid for by the Wollongong Hospital research unit.
Alistair B. Reid, FRACP, Infectious Diseases Department, Level 1, Lawson House, Wollongong Hospital, Crown Street, Wollongong, NSW 2500, Australia, E-mail: email@example.com
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Summary: Postoperative pyoderma gangrenosum is a rare neutrophilic dermatosis that may be confused for necrotizing fasciitis. The inflammatory response is triggered by the trauma of surgery and thus must be managed nonsurgically. Clinical and pathological findings in the 2 diseases can be identical, leading to misdiagnosis and massive surgical defects from the ensuing surgery. This report documents a severe case of postsurgical pyoderma following an elective rotator cuff repair presenting with myositis and myonecrosis. The patient was initially treated as having an infection, which resulted in multiple aggressive surgical debridements. Despite this, the patient continued to deteriorate and was in a critical and hemodynamically unstable condition. Following administration of high-dose intravenous corticosteroids, the patient made a dramatic recovery and went on to have internal fixation of the shoulder and closure of the wound with a combination of a free flap and a rotational flap. Extensive myositis, as seen in this case, has not been previously reported in postoperative pyoderma gangrenosum variants. Clinicians should be aware that the presence of myositis and myonecrosis should not preclude this diagnosis.
Necrotizing fasciitis, a known complication of elective surgery, is an infection characterized by tissue destruction and systemic toxicity with a high mortality that requires aggressive surgical management. By contrast, pyoderma gangrenosum is a rare neutrophilic dermatosis that presents as an inflammatory and ulcerative disorder of the skin with a reported incidence of 0.63 cases per 100,000 person years.1 Postoperative pyoderma is a very rare subset of this disorder where the inflammatory response is triggered by the trauma of surgery and thus must be managed nonsurgically. Clinical and pathological findings in the 2 diseases can be identical leading to misdiagnosis and massive surgical defects from the ensuing surgery.2 This report documents a severe case of postsurgical pyoderma presenting with myositis and myonecrosis.
We present the case of a 55-year-old right-handed man who underwent elective rotator cuff and Bankart repair to the left shoulder. He is a nonsmoker with no comorbidities and taking no medications before surgery. Ten days postoperatively, he presented with pus discharging from the surgical wound. He was not systemically unwell and had no pain or limitation of range of movement.
The patient underwent washout and debridement of the wound, leaving a 14 cm × 7 cm skin defect covered with a vacuum dressing. Flucloxacillin and gentamycin were started postoperatively. The patient returned to theater the following day for repeat shoulder washout despite being clinically well. There was no evidence of necrosis, and the joint appeared normal at both operations. Three days following admission, the patient was febrile to 39°C. Metronidazole and benzylpenicillin were added. On day 4, the patient’s condition declined, and he was again febrile and underwent a third washout. Following surgery, he went into type 1 respiratory failure and required transfer to the critical care unit.
Microscopy and culture to this point were nondiagnostic. Computed tomographic scans performed on day 5 were suggestive of myositis with no gas seen and no collection. The patient’s general condition declined with worsening renal function, fevers, and respiratory deterioration. Antibiotics were changed to ticarcillin/clavulanic acid and vancomycin on day 7. The patient was transferred to our tertiary center on day 12.
On arrival, the patient had a temperature of 39°C, pulse of 100 bpm, and blood pressure of 140/80. On examination, a red, edematous, tender arm was noted with a 15 cm × 7 cm ulcer over the left shoulder. Tissue surrounding the ulcer was woody to touch. The C-reactive protein was 403, and the white cell count was 42,500/mm3. Magnetic resonance imaging showed features of a diffuse myositis, maximal within the deltoid, pectoralis major, coracobrachialis, and serratus anterior, with areas suggesting necrosis within the deltoid and coracobrachialis. The antibiotics were broadened to vancomycin, meropenem, and clindamycin.
The provisional diagnosis was an infective process, either necrotizing fasciitis or myositis, and thus, the patient underwent an extensive washout and radical debridement including pectoralis major, deltoid, serratus anterior, and coracobrachialis. Pathology of these specimens showed acute necrotizing myositis with a mixed inflammatory infiltrate and extensive necrosis and abscess formation. No organisms were isolated.
Postoperative magnetic resonance imaging showed progressive myositis within all rotator cuff muscles, biceps, triceps, and latissimus dorsi (Fig. 1). Despite extensive debridement and 8 operations over 17 days, broad-spectrum antibiotics, hyperbaric oxygen, and silver-coated vacuum dressings, the patient continued to deteriorate and developed hemodynamic instability. The patient was transferred to the intensive care unit for ventilation and inotrope support.
At this point, the diagnosis was not clear. No microorganisms had been identified, including on frozen sections sent during surgery. Rapidly advancing life-threatening systemic toxicity had ensued despite aggressive surgical and medical management. A diagnosis of variant postoperative pyoderma gangrenosum was considered, and the patient was started on hydrocortisone 200 mg IV 6 hourly. Initial improvement was seen within 12 hours, and at 36 hours, the patient had made a dramatic improvement, inotropes were ceased, and the patient had been extubated. Interestingly, the wound changed dramatically and actually looked worse taking on a gray color, which looked like dead tissue; however, it subsequently granulated and showed signs of healing. The patient made a full recovery including internal fixation of the shoulder and closure of the wound with a combination of a free flap and a rotational flap. Reparative surgery was performed under steroid cover (Figs. 2–4).
Pyoderma gangrenosum most commonly involves the skin and subcutaneous tissues and rarely involves the underlying muscle. Extensive myositis, as seen in this case, has not been previously reported in postoperative pyoderma gangrenosum variants.3–21 Postoperative pyoderma has occurred following a wide range of surgeries including breast, abdominal, orthopedic, cutaneous, thyroid, ophthalmic surgery, and permanent pacemaker insertion. It is thought to be mediated by aberrant neutrophil tracking, and the cause is unknown.22 Clinical features include a latency of 6–14 days postoperatively, an inflamed ulcer with an undermined border, and a necrotic base.23 The ulcer is usually well demarcated and may have surrounding erythematous haloes. New lesions may be found at sites of trauma away from the initial lesion. Diagnosis is largely based on clinical features. The failure to isolate pathogenic bacteria on repeated wound and tissue cultures and a failure to respond to broad-spectrum antibiotics would suggest the possibility of pyoderma gangrenosum with an ulcerating surgical wound. The very aggressive course with extensive involvement of muscle resulted in a delay in diagnosis in our case. The slow progression over several weeks and the absence of severe pain also suggested a noninfectious cause. The drastic response to corticosteroid confirmed the diagnosis of postoperative pyoderma gangrenosum variant.
Histopathology may not be helpful as the classic appearance is nonspecific and the necrotizing leukocytoclastic vasculitis with edema and massive neutrophil infiltrate may be indistinguishable from infection. Engorgement and thrombosis of small- and medium-sized vessels with tissue necrosis, hemorrhage, and abscess formation may also be seen.24 Clues to an infectious cause include rapid progression, pain out of proportion to clinical findings, and tissue changes to purple or purple-black.25 In approximately 50% of cases, pyoderma gangrenosum is associated with underlying conditions including rheumatoid arthritis, inflammatory bowel disease, or hematological malignancy.26 We made our diagnosis based on a lack of response to broad-spectrum antibiotics and radical surgical debridement, with multiple tissue biopsies being unrevealing for any sign of infection.
Treatment is largely empirical or based on small series or local experience. Immunosuppressive therapy is the mainstay primarily using corticosteroids or cyclosporine A.23 A small randomized trial of infliximab in standard pyoderma showed benefit over placebo and may be useful in more difficult cases.27
Postoperative pyoderma is a potentially devastating disease that should be considered in the differential diagnosis of postoperative wound infection. This case had many features of postoperative pyoderma gangrenosum, but extensive involvement of muscle caused a delay in diagnosis. The presence of myositis and myonecrosis should not preclude the diagnosis of postoperative pyoderma gangrenosum.
1. Langan SM, Groves RW, Card TR, et al. Incidence, mortality, and disease associations of pyoderma gangrenosum in the United Kingdom: a retrospective cohort study. J Invest Dermatol. 2012;132:2166–2170
2. Mahajan AL, Ajmal N, Barry J, et al. Could your case of necrotising fascitis be pyoderma gangrenosum? Br J Plast Surg. 2005;58:409–412
3. Marie I, Levesque H, Joly P, et al. Neutrophilic myositis as an extracutaneous manifestation of neutrophilic dermatosis. J Am Acad Dermatol. 2001;44:137–139
4. Cullen TS. A progressively enlarging ulcer of the abdominal wall involving skin and fat, following drainage of an abdominal abscess apparently from appendiceal origin. Surg Gynecol Obstet. 1924;38:579–582
5. Ferrandiz-Pulido C, Bartralot R, Fuente MJ, et al. Postoperative pyoderma gangrenosum: diagnostic value of 16s ribosomal RNA sequencing and review of the literature. Clin Exp Dermatol. 2009;34:598–602
6. Kolios L, Hirche C, Ryssel H, et al. [Pyoderma gangraenosum as a major complication in breast reconstruction with free double-DIEP-flap]. Handchir Mikrochir Plast Chir. 2012;44:89–92
7. Iosifescu AG, Boiangiu CI, Comănescu CM, et al. Pyoderma gangrenosum—a postoperative “pseudo-infection”. Chirurgia (Bucur). 2012;107:119–121
8. Wanich T, Swanson AN, Wyatt AJ, et al. Pyoderma gangrenosum following patellar tendon repair: a case report and review of the literature. Am J Orthop (Belle Mead NJ). 2012;41:E4–E9
9. Al Ghazal P, Dissemond J. [Multilocular pyoderma gangrenosum after uterus resection]. Chirurg. 2012;83:254–257
10. Esteve-Martínez A, Coto-Segura P, Garcia-Rabasco A, et al. Pyoderma gangrenosum after thoracic surgery. Ann Thorac Surg. 2011;92:741
11. Reddy R, Favreau T, Stokes T, et al. Pyoderma gangrenosum following breast reconstructive surgery: a case report of treatment with immunosuppression and adjunctive xenogeneic matrix scaffolds. J Drugs Dermatol. 2011;10:545–547
12. de Thomasson E, Caux I. Pyoderma gangrenosum following an orthopedic surgical procedure. Orthop Traumatol Surg Res. 2010;96:600–602
13. Campbell W, Baird E, Murtagh K, et al. Post-operative pyoderma gangrenosum in association with ileal carcinoid tumour. Ulster Med J. 2010;79:102–103
14. Baldea A, Gamelli RL. Postoperative pyoderma gangrenosum after elective abdominoplasty: a case report and review of the literature. J Burn Care Res. 2010;31:959–963
15. Attar S, Spangehl MJ, Casey WJ, et al. Pyoderma gangrenosum complicating bilateral total knee arthroplasty. Orthopedics. 2010;33:441
16. Strauss A, Storim J, Germer CT, et al. Pyoderma gangraenosum as rare complication of incisional hernia repair in a patient with Werlhof’s disease. Hernia. 2011;15:709–712
17. Hawryluk EB, Penn SK, Wasko MC, et al. Treatment of postsurgical pyoderma gangrenosum with a high-potency topical steroid. Ear Nose Throat J. 2010;89:E5–E7
18. Schoemann MB, Zenn MR. Pyoderma gangrenosum following free transverse rectus abdominis myocutaneous breast reconstruction: a case report. Ann Plast Surg. 2010;64:151–154
19. Hornez E, Monchal T, Ottomani S, et al. [Pyoderma gangrenosum mimicking abdominal sepsis after colorectal surgery]. J Chir (Paris). 2009;146:576–578
20. Sebastian VA, Carroll BT, Jessen ME. Pyoderma gangrenosum associated with chronic idiopathic myelofibrosis after coronary artery bypass graft surgery. Interact Cardiovasc Thorac Surg. 2010;10:135–137
21. Duncan A, Bharati A, Wu J, et al. Pyoderma gangrenosum following pacemaker insertion. Clin Exp Dermatol. 2009;34:444–445
22. Wollina U. Pyoderma gangrenosum—a review. Orphanet J Rare Dis. 2007;2:19
23. Schöfer H, Baur S. Successful treatment of postoperative pyoderma gangrenosum with cyclosporin. J Eur Acad Dermatol Venereol. 2002;16:148–151
24. Ruocco E, Sangiuliano S, Gravina AG, et al. Pyoderma gangrenosum: an updated review. J Eur Acad Dermatol Venereol. 2009;23:1008–1017
25. Barr KL, Chhatwal HK, Wesson SK, et al. Pyoderma gangrenosum masquerading as necrotizing fasciitis. Am J Otolaryngol. 2009;30:273–276
26. Crowson AN, Mihm MC Jr, Magro C. Pyoderma gangrenosum: a review. J Cutan Pathol. 2003;30:97–107
27. Brooklyn TN, Dunnill MG, Shetty A, et al. Infliximab for the treatment of pyoderma gangrenosum: a randomised, double blind, placebo controlled trial. Gut. 2006;55:505–509
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