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Memantine in the Treatment and Prophylaxis of Bipolar II Disorder and Comorbid Fibromyalgia: A Case Report

SERRA, GIULIA MD; DE CHIARA, LAVINIA MD; KOUKOPOULOS, ALEXIA EMILIA MD; KOUKOPOULOS, ATHANASIOS MD; SERRA, GINO MD; KAHN, DAVID A. MD

Journal of Psychiatric Practice: May 2014 - Volume 20 - Issue 3 - p 232–236
doi: 10.1097/01.pra.0000450324.44661.12
Clinical Case Discussions

We have recently reported that memantine has a clinically relevant antimanic and long-lasting mood-stabilizing effect in treatment-resistant bipolar disorders, both as augmenting agent and as monotherapy. We have also observed an acute antimanic and sustained mood-stabilizing effect in a small number of patients with bipolar I disorder who had had minimal previous pharmacotherapy. In this article, we report the case of a young woman suffering from bipolar II disorder with associated fibromyalgia, in whom memantine showed an acute antimanic and a long-term prophylactic effect on both bipolar disorder as well as the associated fibromyalgia syndrome. (Journal of Psychiatric Practice 2014;20:232–236)

GIULIA SERRA, DE CHIARA, and ALEXIA E. KOUKOPOULOS: Sapienza University, NeSMOS Department, Sant’Andrea Hospital and Centro Lucio Bini, Rome, Italy; ATHANASIOS KOUKOPOULOS: Centro Lucio Bini, Rome; GINO SERRA: University of Sassari, Italy; KAHN: Columbia University College of Physicians and Surgeons, New York.

Athanasios Koukopoulos died on April 20, 2013.

The authors thank Denis Greenan for his important contribution to the drafting of this report.

The authors declare no conflicts of interest.

© 2014 by Lippincott Williams & Wilkins, Inc.