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Journal of Psychiatric Practice:
doi: 10.1097/01.pra.0000435038.91049.cb
COLUMNS: Psychopharmacology

Complexities of Personalized Medicine: How Genes, Drug-Drug Interactions, Dosing Schedules, and Other Factors Can Combine to Produce Clinically Meaningful Differences in a Drug’s Effect

PRESKORN, SHELDON H. MD

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Abstract

Given increased knowledge from molecular biology and pharmacology, it is apparent that multiple factors can interact to produce clinically meaningful differences in a drug’s effect in specific individuals (i.e., personalized medicine). This topic is discussed in this column using iloperidone as an example. The variables discussed include dose, dosing schedule, genes, drug-drug interactions, and other medical factors. How such variables can combine to alter a drug’s effect is illustrated with a case example and the results of a thorough QTc study of iloperidone. (Journal of Psychiatric Practice 2013;19:397–405)

Copyright © 2013 Lippincott Williams & Wilkins Inc.

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