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Hyperprolactinemia in a Patient with a Pituitary Adenoma Receiving Antipsychotic Drug Therapy

CARROLL, RICHARD W. MB ChB*; CHRISTODOULOU, POLYXENI MB ChB; BAYNES, KEVIN C. R. MBBS PhD; KAHN, DAVID A. MD

Journal of Psychiatric Practice: March 2012 - Volume 18 - Issue 2 - p 126–129
doi: 10.1097/01.pra.0000413279.95843.b5
Clinical Case Discussion

Hyperprolactinemia is a common consequence of treatment with an antipsychotic medication. It can result in hypogonadism due to the inhibitory effect of elevated prolactin levels on the hypothalamic-pituitary-gonadal hormonal axis. We present a case of hypogonadism secondary to hyperprolactinemia in a patient taking antipsychotic medication, with radiological evidence of a pituitary microadenoma. The relevance and investigation of hyperprolactinemia in patients being treated with antipsychotic medications are discussed. (Journal of Psychiatric Practice 2012;18:126–129)

*Wellington Regional Hospital, Capital and Coast DHB, New Zealand

Ealing Hospital NHS Trust, Southall, UK

Columbia University College of Physicians and Surgeons

© 2012 Lippincott Williams & Wilkins, Inc.