This video demonstrates Dr. Wu’s Microbotox injection technique for the lower face and neck. Microbotox is the injection of multiple microdroplets of diluted OnabotulinumtoxinA into the dermis or the interface between the dermis and the superficial layer of facial muscles. The intention is to decrease sweat and sebaceous gland activity in order to improve skin texture and sheen as well as to target the superficial layer of muscles that find attachment to the undersurface of the dermis causing visible rhytids. From the PRS supplement, “Soft Tissue Fillers and Neuromodulators: International and Multidisciplinary Perspectives” (vol 136, issue 5s). The techniques presented in this supplement to Plastic and Reconstructive Surgery do not necessarily represent best practices or endorsed techniques of the Guest Editors, Editor-in-Chief, Editorial Board, American Society of Plastic Surgeons (ASPS) or Wolters Kluwer Health. The videos in this supplement are intended to provide multidisciplinary, international perspectives on how specific Soft Tissue Filler and Neuromodulator products are being used by board-certified plastic surgeons, dermatologists, facial plastic surgeons, and oculoplastic surgeons worldwide and may contain off-label uses in your region. It is recommended that these techniques only be administered by board-certified physicians who are core-trained in cosmetic medicine and according to the product labeling recommended by the U.S. Food and Drug Administration. Publication of these supplements does not constitute product or sponsor endorsement by Journal or ASPS.