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Evaluation of the Upper Limb Lymphatic System: A Prospective Lymphoscintigraphic Study in Melanoma Patients and Healthy Controls

Yamamoto, Takumi M.D., Ph.D.; Yamamoto, Nana M.D.; Ishiura, Ryohei M.D.

Plastic and Reconstructive Surgery: April 2017 - Volume 139 - Issue 4 - p 1028e–1029e
doi: 10.1097/PRS.0000000000003204
Letters

Department of Plastic Surgery, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan

Correspondence to Dr. Takumi Yamamoto, Department of Plastic Surgery, Tokyo Metropolitan Bokutoh Hospital, 4-23-15 Kotobashi, Sumida-ku, Tokyo 130-0022, Japan, tyamamoto-tky@umin.ac.jp

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Sir:

We read with great interest the article entitled “Evaluation of the Upper Limb Lymphatic System: A Prospective Lymphoscintigraphic Study in Melanoma Patients and Healthy Controls” by Rossi et al. (Plast Reconstr Surg. 2016;138:1321–1331).1 Their work is of clinical significance in that they elucidated wide differences and delayed transit of tracer on lymphoscintigraphy in healthy controls, questioning the use of the contralateral limb as a control in lymphedema evaluation using lymphoscintigraphy.

The prospective controlled trial satisfied us, because we have been questioning the value of lymphoscintigraphy with regard to reliability for detecting abnormal lymph circulation. Although lymphoscintigraphy is widely used as the gold standard for lymphedema evaluation, we have seen many cases where lymphoscintigraphy cannot detect abnormal lymph circulation in lymphedema patients (low sensitivity), and “abnormal” lymphoscintigraphic findings such as tracer transit delay are observed in normal control limbs (low specificity) as the study by Rossi et al. clarified.2,3 For lymphedema evaluation, high sensitivity and specificity are required, because many other conditions mimic lymphedema, and no symptom is manifested in subclinical or early lymphedema.2

As we have previously reported, indocyanine green lymphography can visualize superficial lymph flow very clearly in real time without radiation exposure.2–5 Although only superficial lymph flow can be visualized, indocyanine green lymphography allows accurate diagnosis and severity staging of lymphedema with higher sensitivity and specificity compared with lymphoscintigraphy, which enables precise evaluation of primary and secondary lymphedema of various body parts such as arm, leg, face, and genitals.2–5 Lymphoscintigraphy cannot allow accurate diagnosis of subclinical and early lymphedema because of its poor visualization of early changes of lymph circulation. In contrast, indocyanine green lymphography allows precise diagnosis and severity stratification of subclinical and early-stage lymphedema with different prognoses: dermal backflow stage 0, with no dermal backflow pattern (no lymphedema); dermal backflow stage I, with mild dermal backflow pattern (splash pattern, subclinical lymphedema), and dermal backflow stage II, with moderate dermal backflow pattern (stardust pattern, early lymphedema).2,3,5 Although Rossi et al. did not use indocyanine green lymphography in their study, we are confident that indocyanine green lymphography would allow differentiation of findings between the study group and the control group.

Although useful for assessing deep lymph flow such as in abdominal and thoracic lymph circulation, lymphoscintigraphy cannot accurately assess peripheral lymphodynamics, especially at an early stage of lymphedema. Because early diagnosis and treatment is critical for control or cure of lymphedema, an imaging modality with high sensitivity should be used for follow-up of patients at high risk of lymphedema after cancer treatment. Although indocyanine green lymphography is considered one of the best modalities for early diagnosis and routine follow-up, there are several modalities with high accuracy for early diagnosis of lymphedema, such as magnetic resonance lymphography, computed tomography lymphography, and ultrasonographic lymphography; they may be more useful for early diagnosis compared with lymphoscintigraphy. It may be time to reconsider the gold standard for diagnosis of lymphedema, and further comparative studies are warranted to determine the best modality or the best combination for accurate evaluation of lymphedema.

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ACKNOWLEDGMENT

This report was supported, in part, by Tokyo Metropolitan Clinical Research Grant for Special Research H280402001 (to T.Y.).

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DISCLOSURE

The authors have no financial interest to declare in relation to the content of this communication.

Takumi Yamamoto, M.D., Ph.D.

Nana Yamamoto, M.D.

Ryohei Ishiura, M.D.

Department of Plastic Surgery

Tokyo Metropolitan Bokutoh Hospital

Tokyo, Japan

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REFERENCES

1. Rossi M, Grassi R, Costa R, et alEvaluation of the upper limb lymphatic system: A prospective lymphoscintigraphic study in melanoma patients and healthy controls. Plast Reconstr Surg. 2016;138:1321–1331.
2. Yamamoto T, Matsuda N, Doi K, et alThe earliest finding of indocyanine green lymphography in asymptomatic limbs of lower extremity lymphedema patients secondary to cancer treatment: The modified dermal backflow stage and concept of subclinical lymphedema. Plast Reconstr Surg. 2011;128:314e–321e.
3. Yamamoto T, Narushima M, Yoshimatsu H, et alDynamic indocyanine green (ICG) lymphography for breast cancer-related arm lymphedema. Ann Plast Surg. 2014;73:706–709.
4. Yamamoto T, Yoshimatsu H, Narushima M, Yamamoto N, Hayashi A, Koshima IIndocyanine green lymphography findings in primary leg lymphedema. Eur J Vasc Endovasc Surg. 2015;49:95–102.
5. Yamamoto T, Iida T, Matsuda N, et alIndocyanine green-enhanced lymphography for upper extremity lymphedema: A novel severity staging system using dermal backflow patterns. Plast Reconstr Surg. 2011;128:941–947.
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