I agree with Dr. Segal that this article would have been scientifically more powerful had we accurately confirmed that the twins in our study were monozygotic. However, considering that this study was not about organ transfer or life-threatening conditions and considering the costs of additional studies and the inconvenience for the twins, we chose to recruit identical twins based on history. Twins were asked whether they were identical or fraternal and to indicate whether a formal test was ever performed to confirm their zygosity. We are confident that the overwhelming majority, if not all, of the subjects fall into the category of monozygotic twins. Again, Dr. Segal’s concern is valid and we will consider her suggestions in our future studies.
The author has no financial interest to declare in relation to the content of this communication.
Bahman Guyuron, M.D.
University Hospitals Case Medical Center
29017 Cedar Road
Cleveland (Lyndhurst), Ohio 44124
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