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Wound Healing: Part I. Basic Science

Janis, Jeffrey E. M.D.; Harrison, Bridget M.D.

Plastic & Reconstructive Surgery:
doi: 10.1097/01.prs.0000437224.02985.f9

Learning Objectives: After studying this article, the participant should be able to: 1. Describe the basic physiologic events in normal wound healing. 2. Understand the differences in healing among skin, bone, cartilage, and tendon. 3. Identify factors that may compromise or delay wound healing. 4. Describe methods for optimal closure of a wound.

Summary: Understanding the physiology and pathophysiology of normal wound healing and potential impediments to its end will allow the plastic surgeon to maximize postoperative outcomes and, in some instances, avoid unnecessary surgical interventions. Continuous advancements in our understanding of this process require frequent reviews of available data to permit reliable, evidence-based recommendations for clinical application. This is the first of a two-part article summarizing the science and clinical recommendations necessary for successful wound healing.

Author Information

Colombus, Ohio; and Dallas, Texas

From the Department of Plastic Surgery, Ohio State University Medical Center; and Department of Plastic Surgery, University of Texas Southwestern Medical Center.

Received for publication February 3, 2013; accepted April 16, 2013.

Disclosure: Dr. Janis is a member of the advisory board for Integra LifeSciences and a consultant for LifeCell. Dr. Harrison has no financial disclosures.

Jeffrey E. Janis, M.D., Department of Plastic Surgery, Ohio State University, Wexner Medical Center, 915 Olentangy River Road, Suite 2100, Room 2114, Columbus, Ohio 43212,

©2014American Society of Plastic Surgeons