Summary: Soft-tissue fillers have been applied throughout the face; however, the literature has largely ignored the injection of fillers into the nasal anatomy. This Special Topic article reviews proper filler choice and injection technique for the nose based on the senior author’s (R.J.R.) experience. Discussion includes indications for soft-tissue filler injection into the nose as well as specific technical pearls based on filler material, anatomic area, and potential complications. The application of soft-tissue fillers to rhinoplasty has certainly broadened the nasal surgeon’s armamentarium. While major structural changes of the nose are best accomplished through surgical alteration of the osseocartilaginous framework, soft-tissue fillers offer an excellent method to augment areas or refine irregularities. These often subtle alterations require precise preinjection nasal analysis.