Plastic and Reconstructive Surgery

Skip Navigation LinksHome > November 2011 - Volume 128 - Issue 5 > Comparison of Implant-Based Immediate Breast Reconstruction...
Plastic & Reconstructive Surgery:
doi: 10.1097/PRS.0b013e31822b6637
Breast: Original Article

Comparison of Implant-Based Immediate Breast Reconstruction with and without Acellular Dermal Matrix

Vardanian, Andrew J. M.D.; Clayton, John L. M.D., Ph.D.; Roostaeian, Jason M.D.; Shirvanian, Vaheh M.D.; Da Lio, Andrew M.D.; Lipa, Joan E. M.D., M.Sc.; Crisera, Christopher M.D.; Festekjian, Jaco H. M.D.

Collapse Box


Background: Acellular dermal matrix is frequently used in implant-based breast reconstruction to cover the inferior aspect of the breast pocket. Its performance profile remains equivocal. The authors studied whether adding it in implant-based immediate breast reconstruction improved outcomes when compared with non–acellular dermal matrix reconstruction.

Methods: Patients undergoing implant-based immediate breast reconstruction at a single academic medical center were evaluated. Aesthetic outcomes and postoperative complications were assessed and direct comparisons were made between acellular dermal matrix and non–acellular dermal matrix cohorts.

Results: A total of 203 patients underwent 337 immediate expander-based breast reconstructions [with acellular dermal matrix, n = 208 (61.7 percent); without, n = 129 (38.3 percent)]. Patient characteristics, including age at time of reconstruction (mean, 49 ± 11 versus 47 ± 10 years) and body mass index (mean, 23 ± 5 versus 23 ± 3 kg/m2) were similar between groups (p > 0.05). Complications occurred in one-third of patients (33.5 percent). In univariate analyses, acellular dermal matrix use had fewer overall complications (odds ratio, 0.61; 95 percent CI, 0.38 to 0.97). The incidences of seroma/hematoma (p = 0.59), infection (p = 0.31), and wound complications (p = 0.26) did not differ. Aesthetic outcomes were higher in the acellular dermal matrix group. In multivariate logistic regression, acellular dermal matrix use was associated with less capsular contracture (odds ratio, 0.18; 95 percent CI, 0.08 to 0.43) and mechanical shift (odds ratio, 0.23; 95 percent CI, 0.06 to 0.78).

Conclusions: Optimizing the inframammary fold with acellular dermal matrix creates a superior aesthetic result. Its use appears safe and is associated with less capsular contracture and mechanical shift and improvement in the inframammary fold appearance, without increasing postoperative complications.


©2011American Society of Plastic Surgeons


Article Tools


Article Level Metrics

The Clinical Masters of PRS – Breast eBooks

4 Essential eBooks for Plastic Surgeons