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The Oncologic Outcome and Immediate Surgical Complications of Lipofilling in Breast Cancer Patients: A Multicenter Study—Milan-Paris-Lyon Experience of 646 Lipofilling Procedures

Petit, Jean Yves M.D.; Lohsiriwat, Visnu M.D.; Clough, Krishna B. M.D.; Sarfati, Isabelle M.D.; Ihrai, Tarik M.D.; Rietjens, Mario M.D.; Veronesi, Paolo M.D.; Rossetto, Fabio B.S.; Scevola, Anna M.D.; Delay, Emmanuel M.D.

Plastic and Reconstructive Surgery: August 2011 - Volume 128 - Issue 2 - p 341-346
doi: 10.1097/PRS.0b013e31821e713c
Breast: Original Articles
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Background: Lipofilling is now performed to improve the breast contour, after both breast-conserving surgery and breast reconstruction. However, injection of fat into a previous tumor site may create a new environment for cancer and adjacent cells. There is also no international agreement regarding lipofilling after breast cancer treatment.

Methods: The authors included three institutions specializing in both breast cancer treatment and breast reconstruction (European Institute of Oncology, Milan, Italy; Paris Breast Center, Paris, France; and Leon Berard Centre, Lyon, France) for a multicenter study. A collective chart review of all lipofilling procedures after breast cancer treatment was performed.

Results: From 2000 to 2010, the authors reviewed 646 lipofilling procedures from 513 patients. There were 370 mastectomy patients and 143 breast-conserving surgery patients. There were 405 patients (78.9 percent) with invasive carcinoma and 108 (21.1 percent) with carcinoma in situ. The average interval between oncologic surgical interventions and lipofilling was 39.7 months. Average follow-up after lipofilling was 19.2 months. The authors observed a complication rate of 2.8 percent (liponecrosis, 2.0 percent). Twelve radiologic images appeared after lipofilling in 119 breast-conserving surgery cases (10.1 percent). The overall oncologic event rate was 5.6 percent (3.6 percent per year). The locoregional event rate was 2.4 percent (1.5 percent per year).

Conclusions: Lipofilling after breast cancer treatment leads to a low complication rate and does not affect radiologic follow-up after breast-conserving surgery. A prospective clinical registry including high-volume multicenter data with a long follow-up is warranted to demonstrate the oncologic safety. Until then, lipofilling should be performed in experienced hands, and a cautious oncologic follow-up protocol is advised.

CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.

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Milan, Italy; Paris and Lyon, France; and Bangkok, Thailand

From the Division of Plastic and Reconstructive Surgery, European Institute of Oncology; the Paris Breast Center; the Leon Berard Center; and the Department of Surgery, Siriraj Hospital, Mahidol University.

Received for publication October 21, 2010; accepted January 14, 2011.

Disclosure:The authors have no conflict of interest to report. No outside funding was received.

Jean Yves Petit, M.D., Division of Plastic Surgery, European Institute of Oncology, Via Ripamonti, 435, 20141 Milano, Italy, jean.petit@ieo.it

©2011American Society of Plastic Surgeons