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Basic Science Review on Adipose Tissue for Clinicians

Brown, Spencer A. Ph.D.; Levi, Benjamin M.D.; Lequex, Charlotte; Wong, Victor W. M.D.; Mojallal, Ali M.D.; Longaker, Michael T. M.D., M.B.A.

Plastic and Reconstructive Surgery: December 2010 - Volume 126 - Issue 6 - p 1936-1946
doi: 10.1097/PRS.0b013e3181f44790
Experimental: Scientific Review

Summary: The recognition that fat contains stem cells has driven further examination into the potential uses of fat and adipose-derived stem cells in a wide number of clinical situations. New information about the harvesting, isolation, and subsequent differentiation properties of isolated adipose-derived stem cells has led to new research into novel tissue-engineered constructs and the transformation of adipose-derived stem cells to induced pluripotent stem cells. Clinically, use of fat grafts and adipose-derived stem cells worldwide and in the United States has dramatically increased in parallel to questions concerning the safety and efficacy of adipose-derived stem cell–based treatments. Currently, the U.S. Food and Drug Administration has not approved the use of isolated adipose-derived stem cells for medical indications.

Dallas, Texas; and Stanford, Calif.

From the Department of Plastic Surgery, University of Texas Southwestern Medical Center, and the Department of Surgery, Division of Plastic Surgery, Stanford University School of Medicine.

Received for publication January 20, 2010; accepted June 9, 2010.

Disclosure:The authors have no financial interest to declare in relation to the content of this article.

Spencer A. Brown, Ph.D., Department of Plastic Surgery, University of Texas Southwestern Medical Center, 1801 Inwood Road, Dallas, Texas 75390-8560

©2010American Society of Plastic Surgeons