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First U.S. Near-Total Human Face Transplantation: A Paradigm Shift for Massive Complex Injuries

Siemionow, Maria Z. M.D., Ph.D., D.Sc.; Papay, Frank M.D.; Djohan, Risal M.D.; Bernard, Steven M.D.; Gordon, Chad R. D.O.; Alam, Daniel M.D.; Hendrickson, Mark M.D.; Lohman, Robert M.D.; Eghtesad, Bijan M.D.; Fung, John M.D.

Plastic & Reconstructive Surgery: January 2010 - Volume 125 - Issue 1 - pp 111-122
doi: 10.1097/PRS.0b013e3181c15c4c
Reconstructive: Head and Neck: Original Articles
Discussion
Basic

Background: Severe complex facial injuries are difficult to reconstruct and require multiple surgical procedures. The potential of performing complex craniofacial reconstruction in one surgical procedure is appealing, and composite face allograft transplantation may be considered an alternative option. The authors describe establishment of the Cleveland Clinic face transplantation program that led them to perform the first U.S. near-total face transplantation.

Methods: In November of 2004, the authors received the world's first institutional review board approval to perform a face transplant in humans. In December of 2008, after a 22-hour operation, the authors performed the first near-total face transplantation in the United States, replacing 80 percent of the patient's traumatic facial deficit with a composite allograft from a brain-dead donor. This largest, and most complex, face allograft in the world included over 535 cm2 of facial skin; functional units of full nose with nasal lining and bony skeleton; lower eyelids and upper lip; underlying muscles and bones, including orbital floor, zygoma, maxilla, alveolus with teeth, hard palate, and parotid glands; and pertinent nerves, arteries, and veins. Immunosuppressive treatment consisted of thymoglobulin, tacrolimus, mycophenolate mofetil, and prednisone.

Results: The patient tolerated the procedure and immunosuppression well. At day 47 after transplantation, routine biopsy showed rejection of the graft mucosa without clinical evidence of skin or graft rejection. The patient's physical and psychological recovery went well. The functional outcome has been excellent, including optimal return of breathing through the nose, smelling, tasting, speaking, drinking from a cup, and eating solid foods.

Conclusion: The functional outcome thus far at 8 months is rewarding and confirms the feasibility of performing complex reconstruction of severely disfigured patients in a single surgical procedure of facial allotransplantation.

Cleveland, Ohio

From the Department of Plastic and Reconstructive Surgery, Cleveland Clinic.

Received for publication July 22, 2009; accepted September 4, 2009.

Presented at the 88th Annual Meeting of the American Association of Plastic Surgeons, in Palm Springs, California, March 21 through 24, 2009.

Disclosures: None of the authors has any commercial associations or financial disclosures that might pose or create a conflict of interest with information presented in the article.

Maria Z. Siemionow, M.D., Ph.D., D.Sc.; Department of Plastic and Reconstructive Surgery; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195; siemiom@ccf.org

Correction: First U.S. Near-Total Human Face Transplantation: A Paradigm Shift for Massive Complex Injuries

The year given in the next to last sentence of the “Transplantation Procedure” paragraph (on p. 113) is incorrect. The sentence should read, “After 22 hours, the successful operation was completed on December 10, 2008.“

This correction is published in the February 2010 issue of the Journal.

©2010American Society of Plastic Surgeons