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Percutaneous Collagen Induction Therapy: An Alternative Treatment for Scars, Wrinkles, and Skin Laxity

Aust, Matthias C. M.D.; Fernandes, Des M.D.; Kolokythas, Perikles M.D.; Kaplan, Hilton M. M.D.; Vogt, Peter M. M.D.

Plastic & Reconstructive Surgery:
doi: 10.1097/01.prs.0000304612.72899.02
Cosmetic: Original Articles
Abstract

Background: Skin laxity, rhytides, and photoaging are generally treated by ablative procedures that injure or destroy the epidermis and its basement membrane, at least in the beginning, and subsequently lead to fibrosis of the papillary dermis. The ideal treatment would be to preserve the epidermis and promote normal collagen and elastin formation in the dermis. Percutaneous collagen induction takes us closer to this ideal.

Methods: The authors performed a retrospective analysis of 480 patients in South Africa and Germany with fine wrinkles, lax skin, scarring, and stretch marks treated with percutaneous collagen induction using the Medical Roll-CIT to produce tighter, smoother skin. Most patients had only one treatment, but some have had as many as four treatments. Patients were prepared with topical vitamin A and C cosmetic creams for a minimum of 4 weeks preoperatively.

Results: On average, patients in Germany rated their improvement between 60 and 80 percent better than before the treatment. Histologic examination was carried out in 20 patients and showed a considerable increase in collagen and elastin deposition at 6 months postoperatively. The epidermis demonstrated 40 percent thickening of stratum spinosum and normal rete ridges at 1 year postoperatively.

Conclusions: Percutaneous collagen induction was started in 1997 and has proved to be a simple and fast method for safely treating wrinkles and scars. As opposed to ablative laser treatments, the epidermis remains intact and is not damaged. For this reason, the procedure can be repeated safely and is also suited to regions where laser treatments and deep peels cannot be performed.

Author Information

Hannover, Germany; Cape Town, South Africa; and Los Angeles, Calif.

From the Klinik für Plastische, Hand- und Wiederherstellungschirurgie, Medizinische Hochschule Hannover; Department of Plastic and Reconstructive Surgery, Groote Schuur Hospital; and Department of Biomedical Engineering, University of Southern California.

Received for publication November 17, 2006; accepted February 28, 2007.

Disclosures: Dr. Des Fernandes is employed as the senior medical consultant for Environ Skin Care Pty. Ltd. (South Africa), whose products were used by all the patients in this report. He does not own any equity in Environ Skin Care Pty. Ltd. The Roll-Cit products are made by Vivida Closed Corporation. Dr. Des Fernandes is a shareholder in Vivida Closed Corporation and is employed by Vivida as a medical consultant. Dr. Matthias Aust is the medical consultant for Care Concept, distributors for Environ Skin Care Products and Roll-Cit in Germany. Dr. Hilton Kaplan is the medical advisor to DermoGenesis, USA, a U.S. distributor of Environ. Prof. Vogt and Dr. Kolokythas have no sources of funds supporting the work and no financial interest in any of the products, devices, or drugs mentioned in this article.

Matthias C. Aust, M.D., Klinik für Plastische, Hand- und Wiederherstellungschirurgie, Hochschule Hannover, Carl-Neuberg Straβe 1, Hannover 30625, Germany, aust_matthias@gmx.de

©2008American Society of Plastic Surgeons