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An Antibiotic Order Form Intervention Does Not Improve or Reduce Vancomycin Use

Bolon, Maureen K. MD, MS*; Arnold, Alana D. PharmD; Feldman, Henry A. PhD; Goldmann, Donald A. MD§; Wright, Sharon B. MD, MPH

The Pediatric Infectious Disease Journal: December 2005 - Volume 24 - Issue 12 - p 1053-1058
doi: 10.1097/01.inf.0000190025.61037.6c
Original Studies

Objectives: To determine whether a paper-based antibiotic ordering system is an effective antibiotic stewardship measure.

Methods: An antibiotic order form (AOF) was introduced in July 2001 at a pediatric tertiary care hospital. Vancomycin courses prescribed before and after the AOF introduction were retrospectively reviewed based on Hospital Infection Control Practices Advisory Committee guidelines. The impact of the AOF on the appropriateness of vancomycin prescribing was evaluated in univariate and multivariable analyses that adjusted for other factors associated with appropriateness of vancomycin use. The density of vancomycin use after introduction of the AOF was also assessed.

Results: Compliance with the AOF was poor (<50%) during the planned study period; therefore an additional 2 months of improved compliance (70–80%) were included. Rates of inappropriate vancomycin use increased during the study periods: 35% before AOF; 39% post-AOF; and 51% during the improved compliance period. On adjusted analysis, vancomycin utilization was significantly more inappropriate after introduction of the AOF. Vancomycin doses per 1000 patient days increased after introduction of the AOF.

Conclusions: Inappropriate vancomycin use and vancomycin use overall increased after the introduction of an AOF. An AOF intervention did not have its intended effect of improving and reducing vancomycin use.

From the *Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL; the †Department of Pharmacy, the ‡Clinical Research Program and the §Division of Infectious Diseases, Children's Hospital Boston, Boston, MA; and the ‖Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA

Accepted for publication July 11, 2005.

Presented in abstract form at the 13th Annual Scientific Meeting of The Society for Healthcare Epidemiology of America, 2003, Arlington, VA.

E-mail m-bolon@northwestern.edu. Reprints not available.

© 2005 Lippincott Williams & Wilkins, Inc.