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Pediatric Infectious Disease Journal:
3. Prevention and Treatment

Duration of Immunity Against Pertussis After Natural Infection or Vaccination

Wendelboe, Aaron M. MSPH*; Van Rie, Annelies MD, PhD*; Salmaso, Stefania PhD†; Englund, Janet A. MD‡

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Despite decades of high vaccination coverage, pertussis has remained endemic and reemerged as a public health problem in many countries in the past 2 decades. Waning of vaccine-induced immunity has been cited as one of the reasons for the observed epidemiologic trend. A review of the published data on duration of immunity reveals estimates that infection-acquired immunity against pertussis disease wanes after 4–20 years and protective immunity after vaccination wanes after 4–12 years. Further research into the rate of waning of vaccine-acquired immunity will help determine the optimal timing and frequency of booster immunizations and their role in pertussis control.

© 2005 Lippincott Williams & Wilkins, Inc.


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